[Freesurfer] Tutorial for linear mixed model toolbox

2014-01-03 Thread sabin khadka
Hi all,

I was just wondering if there is a tutorial or example on how to use 
linear mixed effect model toolbox for longitudinal analysis.
I already processed my structural images with longitudinal processing pipeline 
from freesurfer. I want to do group analysis where I have 4 groups with 
N~20-30 on each group for time T1 and T2 scans in duration of ~2 years. I am 
kind of in confusion on how to proceed like making qdec.table.dat and contrast 
matrix and all.


Thanks for help

-- 

Cheers,
Sabin ___
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Re: [Freesurfer] Tutorial for linear mixed model toolbox

2014-01-03 Thread Martin Reuter

Hi Sabin,

there is no tutorial, but a detailed description here (with examples):
https://surfer.nmr.mgh.harvard.edu/fswiki/LinearMixedEffectsModels

the long.qdec table is just a text file and described, for example, here:
https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/LongitudinalTutorial_freeview#LongitudinalQDECTable

The trickiest part for you will be to setup the model and that depends 
on the analysis you want to do (what co-variates to include, are some 
time varying, fixed and mixed effects). As that can get more involved we 
recommend to include a bio-statistician or read up on the statistics.


This is a good book (but you need some math background):
http://www.hsph.harvard.edu/fitzmaur/ala/

Best, Martin

On 01/03/2014 10:07 AM, sabin khadka wrote:

Hi all,

I was just wondering if there is a tutorial or example on how to use 
linear mixed effect model toolbox for longitudinal analysis.
I already processed my structural images with longitudinal processing 
pipeline from freesurfer. I want to do group analysis where I have 4 
groups with N~20-30 on each group for time T1 and T2 scans in duration 
of ~2 years. I am kind of in confusion on how to proceed like making 
qdec.table.dat and contrast matrix and all.


Thanks for help

--
Cheers,
Sabin


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Martin Reuter, Ph.D.
Assistant in Neuroscience - Massachusetts General Hospital
Instructor in Neurology   - Harvard Medical School
MGH / HMS / MIT

A.A.Martinos Center for Biomedical Imaging
149 Thirteenth Street, Suite 2301
Charlestown, MA 02129

Phone: +1-617-724-5652
Email:
   mreu...@nmr.mgh.harvard.edu
   reu...@mit.edu
Web  : http://reuter.mit.edu

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