Re: [FRIAM] saRNA

[David Eric Smith]

Yeah.  

My first thought on looking at this was that getting the dosing right is going 
to be a bear.  Now you not only have to deal with variation among people in 
mRNA expression levels, but you have to manage variation in the amplifier by an 
RDRP (RNA-dependent RNA polymerase).  

My thoughts drifted to financial derivatives, which can be used to hedge a 
portfolio to smooth out fluctuations in the underlying, because a little money 
with a big amplifier can be used to purchase an insurance contract.  What could 
go wrong?

Also drifted to Hilary’s snapchat, and the robustness of things that don’t have 
too many layers of internal distribution and persistence: “These messages go 
away by themselves” was probably one of the things that made the original mRNA 
vaccines as manageable as they were.

But, engineers gonna engineer.  Will be interesting to see what the news is as 
more gets done.

Eric


> On Sep 10, 2023, at 1:08 PM, glen  wrote:
> 
> https://sciencebasedmedicine.org/self-amplifying-rna-vaccines/?utm_source=rss_medium=rss_campaign=self-amplifying-rna-vaccines
>  
> 
> 
> "It is also likely that there will be another round of fear-mongering about 
> the new technology. It probably best for scientists to get ahead of this, to 
> introduce and explain the technology to the public, so that at least it will 
> be somewhat familiar before the next COVID. "
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[FRIAM] structure/function in (network) systems

[Steve Smith]

This recent article about synchronization in networks was fascinating to me:

   https://neurosciencenews.com/complex-system-synchronization-23902/

and lead me to need to catch (ever so little) on the idea of structure 
vs process "motif" graphlets


   https://www.math.ucla.edu/~mason/papers/alice-motifs2021.pdf

some (many?) here who are more active and engaged in such work may 
already be up on this stuff...  the world moves on!


or maybe it is just part of the towering mass of ignorance looming over 
my head?
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Re: [FRIAM] saRNA

[Steve Smith]

The space between */Scylla and Charybdis/ *seems to be shrinking by 
halves.   On the one had the conspiracists are "awfulizing" everything 
while others might be "normalizing" everything in the spirit of 
(polyanna?) progress?


With what *appears* to be a sharp rise in auto-immune disorders in the 
(first?) world, I can understand why some might cringe at playing hard 
at the edge of immune system manipulation.  On the other hand, the 
historical pandemics (formerly known as plagues) seem to be naturally 
expanded/aggravated/facilitated by our modern transportation (people and 
goods).


A variation of the Red Queen dilemma?

https://sciencebasedmedicine.org/self-amplifying-rna-vaccines/?utm_source=rss_medium=rss_campaign=self-amplifying-rna-vaccines 



"It is also likely that there will be another round of fear-mongering 
about the new technology. It probably best for scientists to get ahead 
of this, to introduce and explain the technology to the public, so 
that at least it will be somewhat familiar before the next COVID. "


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