I am seeing the same symptoms as reported in #49102. https://debbugs.gnu.org/cgi/bugreport.cgi?bug=49102
$ guix describe Generation 17 May 06 2022 18:17:56 (current) guix 0e94295 repository URL: https://git.savannah.gnu.org/git/guix.git branch: master commit: 0e9429544fd737079b9c1562de3beb48329350a9 I have built guix from the same version (current master). $ ./guix-daemon ./guix-daemon: error while loading shared libraries: libz.so.1: cannot open shared object file: No such file or directory $ ldd ./guix-daemon linux-vdso.so.1 (0x00007ffde5398000) libz.so.1 => not found libsqlite3.so.0 => not found libgcrypt.so.20 => not found libbz2.so.1.0 => not found libstdc++.so.6 => /gnu/store/094bbaq6glba86h1d4cj16xhdi6fk2jl-gcc-10.3.0-lib/lib/libstdc++.so.6 (0x00007f86ad507000) libm.so.6 => /gnu/store/5h2w4qi9hk1qzzgi1w83220ydslinr4s-glibc-2.33/lib/libm.so.6 (0x00007f86ad3c4000) libgcc_s.so.1 => /gnu/store/094bbaq6glba86h1d4cj16xhdi6fk2jl-gcc-10.3.0-lib/lib/libgcc_s.so.1 (0x00007f86ad3aa000) libc.so.6 => /gnu/store/5h2w4qi9hk1qzzgi1w83220ydslinr4s-glibc-2.33/lib/libc.so.6 (0x00007f86ad1e8000) /gnu/store/5h2w4qi9hk1qzzgi1w83220ydslinr4s-glibc-2.33/lib/ld-linux-x86-64.so.2 (0x00007f86ad6de000) Is anyone else seeing this error? Greg