Re: [NMusers] ERROR NUMBER OF BASIC PK PARAMETERS EXCEEDS VALUE OF NPARAM IN $MODEL

[Leonid Gibiansky]

Not sure why would we need NPARAM there, is it necessary? I think one 
can skip it.


On the different topic, expression for IWRES is not correct:

IWRES=IRES/(IPRED * EPS(1) + EPS(2))

This is the version that should be used:

IWRES=IRES/SQRT(IPRED**2 * SIGMA(1,1) + SIGMA(2,2))

Also it is more traditional to define IRES=DV-IPRED (negative residual 
corresponds to over-predictions; observed=predicted + residual error).


Regards
Leonid


On 7/29/2019 2:49 PM, Paul Hutson wrote:
I’ve fixed it by increasing NPARAM until it worked (increasing to 7), 
but can anyone explain why I get this message for a 3 compartment model 
with additional compartments to output a time above a concentration 
threshold (#4) and AUC while above that concentration threshold (#5)?  
It appears that NONMEM wants additional parameters added to NPARAM when 
I added calculated value CC in the $DES block.  What is also odd to me 
is that the fault is called on the line defining DADT(2). Thanks in 
advance. Paul


$SUBROUTINES ADVAN6 TOL=3

$MODEL NCOMP=5 NPARAM=6

COMP=(CENTRAL DEFDOSE DEFOBS)

COMP=(TISU1)

COMP=(TISU2)

COMP=(TTIME)

COMP=(AUCC)

;--PK BLOCK

$PK

MIC=0.12 ; SEEKING TIME AND AUC ABOVE 0.12 MCG/ML

TVCL = POP_CL

TVV1=POP_V1

TVQ2=POP_Q2

TVV2=POP_V2

TVQ3=POP_Q3

TVV3=POP_V3

CL=TVCL * EXP(ETA(1))

V1=TVV1 * EXP(ETA(2))

Q2=TVQ2 * EXP(ETA(3))

V2=TVV2 * EXP(ETA(4))

Q3=TVQ3 * EXP(ETA(5))

V3=TVV3 * EXP(ETA(6))

K10=CL/V1

K12=Q2/V1

K21=Q2/V2

K13=Q3/V1

K31=Q3/V3

;DES BLOCK

$DES

CC=A(1)/V1

RT=0

IF(CC.GT.MIC) RT=1

DADT(1) = - A(1) * (K10 + K12 + K13) + A(2) * K21  + A(3)*K31

DADT(2) = A(1) * K12 - A(2) * K21

DADT(3) = A(1) * K13 - A(3) * K31

DADT(4)=RT ; TIME ABOVE THRESHOLD TAT

DADT(5)=RT*CC ; AUC ABOVE THRESHOLD AUCAT

;- ERROR MODEL --

$ERROR

IPRED = F

    IRES=IPRED-DV

    Y=IPRED * (1 + EPS(1)) + EPS(2)

    IWRES=IRES/(IPRED * EPS(1) + EPS(2))

TAT=A(4)

AUCAT=A(5)

TIS2 = A(2)/V2

TIS3 = A(3)/V3

Paul Hutson, PharmD, BCOP

Professor

UWisc School of Pharmacy

T: 608.263.2496

F: 608.265.5421

[NMusers] ERROR NUMBER OF BASIC PK PARAMETERS EXCEEDS VALUE OF NPARAM IN $MODEL

[Paul Hutson]

I've fixed it by increasing NPARAM until it worked (increasing to 7), but can 
anyone explain why I get this message for a 3 compartment model with additional 
compartments to output a time above a concentration threshold (#4) and AUC 
while above that concentration threshold (#5)?  It appears that NONMEM wants 
additional parameters added to NPARAM when I added calculated value CC in the 
$DES block.  What is also odd to me is that the fault is called on the line 
defining DADT(2). Thanks in advance. Paul

$SUBROUTINES ADVAN6 TOL=3
$MODEL NCOMP=5 NPARAM=6
COMP=(CENTRAL DEFDOSE DEFOBS)
COMP=(TISU1)
COMP=(TISU2)
COMP=(TTIME)
COMP=(AUCC)

;--PK BLOCK
$PK
MIC=0.12 ; SEEKING TIME AND AUC ABOVE 0.12 MCG/ML

TVCL = POP_CL
TVV1=POP_V1
TVQ2=POP_Q2
TVV2=POP_V2
TVQ3=POP_Q3
TVV3=POP_V3

CL=TVCL * EXP(ETA(1))
V1=TVV1 * EXP(ETA(2))
Q2=TVQ2 * EXP(ETA(3))
V2=TVV2 * EXP(ETA(4))
Q3=TVQ3 * EXP(ETA(5))
V3=TVV3 * EXP(ETA(6))

K10=CL/V1
K12=Q2/V1
K21=Q2/V2
K13=Q3/V1
K31=Q3/V3

;DES BLOCK
$DES
CC=A(1)/V1

RT=0
IF(CC.GT.MIC) RT=1

DADT(1) = - A(1) * (K10 + K12 + K13) + A(2) * K21  + A(3)*K31
DADT(2) = A(1) * K12 - A(2) * K21
DADT(3) = A(1) * K13 - A(3) * K31

DADT(4)=RT ; TIME ABOVE THRESHOLD TAT
DADT(5)=RT*CC ; AUC ABOVE THRESHOLD AUCAT
;- ERROR MODEL --
$ERROR
IPRED = F
   IRES=IPRED-DV
   Y=IPRED * (1 + EPS(1)) + EPS(2)
   IWRES=IRES/(IPRED * EPS(1) + EPS(2))
TAT=A(4)
AUCAT=A(5)
TIS2 = A(2)/V2
TIS3 = A(3)/V3

Paul Hutson, PharmD, BCOP
Professor
UWisc School of Pharmacy
T: 608.263.2496
F: 608.265.5421

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[Chao Chen]

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Chao Chen
Clinical Pharmacology Modelling & Simulation
GlaxoSmithKline R


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[NMusers] Postdoc position available at CUHK, Hong Kong

[Xiaoyu Yan]

*Job Description*



   - School of Pharmacy at Chinese University of Hong Kong (CUHK) is
   offering a postdoc positions for 24 months.
   - The project aims to study normal or disease related herb-drug
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*To Apply*

   -
*You can send your CV to xiaoyu...@cuhk.edu.hk  *


Thanks,
Xiaoyu

Assistant Professor

School of Pharmacy

Faculty of Medicine

The Chinese University of Hong Kong

Tel: (852) 3943 5012

Fax: (852) 2603 5295

Email:xiaoyu...@cuhk.edu.hk