Yes. Read the METHOD=CHAIN section in the intro712.pdf manual.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: robert.ba...@iconplc.com
Web: www.icondevsolutions.com
From: Ethan Wu [mailto:ethan.w...@yahoo.com]
Sent: Thursday, September 16, 2010 12:19 PM
To: Bauer, Robert; nmusers@globomaxnm.com
Subject: Re: [NMusers] quality of SE estimate by IMP method
Hi Bob,
Is there a way to pick up from the last run with SAEM/IMP so to only
run the additional step IMPMAP?
Thank you.
From: Bauer, Robert robert.ba...@iconplc.com
To: Ethan Wu ethan.w...@yahoo.com; nmusers@globomaxnm.com
Sent: Thu, September 16, 2010 12:12:28 PM
Subject: RE: [NMusers] quality of SE estimate by IMP method
At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1)
and see if that helps. Let it run for 20 iterations.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: robert.ba...@iconplc.com
Web: www.icondevsolutions.com http://www.icondevsolutions.com/
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Ethan Wu
Sent: Thursday, September 16, 2010 11:46 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] quality of SE estimate by IMP method
Dear uses,
I am using NM7 SAEM method for an analysis. As I learned from NM7
workshop, I used IMP method after SAEM to generate SE estimate.
In this case, at the end of SAEM iteration, OBJ was quite stable and
negative several thousand.
But, with IMP, after 5 iterations, Obj was up to positive several 10
to power of 7. Obj was decreasing during this 5 iterations.
My questions is, dose this mean SE estimate is not reliable? Should I
increase iterations of IMP?
Thank you.
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