Miko Ohtamaa added the comment:

I think there is something more in this. 

I am running Python 3.5.0 (default, Apr 24 2016, 12:47:36).

Sparkpost servers require AUTH LOGIN approach as per their instructions 
https://support.sparkpost.com/customer/portal/articles/1988470-smtp-connection-problems

When trying to use these (free) servers smtplib authentication will result to 
smtplib.SMTPAuthenticationError: (500, b'5.5.2 unrecognized command') like in 
the issue description earlier. I am still investigating this.

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nosy: +miohtama, ned.deily

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<http://bugs.python.org/issue25446>
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