Hi all Dear all, I need to compute boundaries for 3 stages group sequential design with 2 variables using Simpson’s integration method. There is a r program written by Michael A. Proschant et Al. (2006) (Statistical Monitoring of Clinical Trials: A Unified Approach) – see file attached – to calculate boundaries for 1 variable only. Does anyone know how this program can be modified to incorporate a second variable? Or propose an alternative solution please?
Many thanks Jeka http://r.789695.n4.nabble.com/file/n4632450/Boundary.R Boundary.R -- View this message in context: http://r.789695.n4.nabble.com/How-to-compute-boundaries-for-bivariate-normal-distribution-in-group-sequential-design-tp4632450.html Sent from the R help mailing list archive at Nabble.com. ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
