Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
If you want some real fun, sign on to the Taxacom mailing list and post an opinion about whether a particular method is "cladistic" or not. But the heated exchange that might result is already anachronistic. There's an expression in English, "It's all over but the shouting." The shouting will go on for some time, but it's over. Whether or not you agree with it, the matter's settled: the community now very much considers that an organism's identity arises from its genetic history, and that classification should as directly as possible reflect that genetic history. Classification is about words, and it helps very much to have the words we use reflect the concepts that we think matter. Yes, the questions of evolutionary history and classifications can be separated, but I wouldn't say that a confusion between them hampered the progress of evolutionary biology. A battle *within* evolutionary biology between older and newer paradigms as to what emphasis mattered (adaptive zones versus genetic history) was fought with classification as the prize to be won. The fact that most adherents to the new paradigm weren't concerned about classification, and many of the traditionalists were, made it seem to the younger generations as if progress was being hindered by a focus on classification. Of course, since the battle was won long before the shouting stopped, it's understandable why the younger generations felt burdened by the unnecessary shouting. Wayne At 10:43 AM -0700 29.9.2009, Joe Felsenstein wrote: When I wrote: >As what classifications should be, or whether methods should be >considered as making phylogenetic or phenetic classifications, I have my >own position, that no one else seems to back (in public, anyway). I >think that we should not think of these trees as classifications, and not >call them phylogenetic classifications or phenetic classifications, but >consider them as estimates of the phylogeny. The issue of how to classify >is less important anyway. Emmanuel Paradis responded - I have the strong feeling that most users of R and its [phylo]genetics packages are interested in the study of evolutionary processes, not in classification (I rarely see questions about classification or systematics here). So maybe most of us silently back Joe's position. About the issue of how to classify, I think it is very important. The point here is, in my view, that the confusion between classification and evolution greatly hampered the progress of evolutionary biology, but the situation has improved in recent years. I can't speak for most users of R, but I do suspect that Emmanuel is right in that there is agreement with this position among many younger evolutionary biologists. But it is a sufficiently intimidating atmosphere for them that they do not usually say that out loud. I have stuck my neck out, mostly for the fun of it. The reactions among many systematists have been strong -- they are really outraged, and figure that this is just some arbitrary opinion of mine, which they are (barely) willing to tolerate. I suppose the matter will become one of open discussion some day. Anyway, back to R. J.F. Joe Felsenstein j...@gs.washington.edu Department of Genome Sciences and Department of Biology, University of Washington, Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo -- Wayne Maddison Professor and Canada Research Chair Depts. of Zoology and Botany and Biodiversity Research Centre & Director Beaty Biodiversity Museum 6270 University Boulevard University of British Columbia Vancouver, BC V6T 1Z4 Canada email: wmadd...@interchange.ubc.ca FAX: +1 604 822-2416 Mesquite: http://mesquiteproject.org MacClade: http://macclade.org Salticidae: http://salticidae.org Tree of Life: http://tolweb.org Beaty Biodiversity Museum: http://beatymuseum.ubc.ca Home page: http://salticidae.org/wpm/home.html ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Ted said: > One more comment on all of this. From the standpoint of "comparative > methods," some similar things have occurred. In particular, the early > attempts to take evolutionary relationships into account when performing > statistical analyses that compared, say, brain size, were always taxonomic, > in that Class, Order, Family, etc. might be taken into account. This was > done without much thought given to whether the classification used was or > was not very well tied to evolutionary (phylogenetic) relationships for the > particular group under study. ... > Anyway, it took a long time, and perhaps some "unnecessary shouting," to > convince practitioners that *phylogenetic* comparative methods are > fundamentally different from those that are only based on taxonomy, which > can never convey as much information as a detailed (and accurate!) > phylogenetic tree. I got into comparative methods issues after hearing Paul Harvey discuss the earlier ANOVA-style methods that used groups at levels in the classification. I have to say that the people who developed those were actually quite worried about whether that was the right way to go. Compared to the rivers of blood and years of darkness in the fighting over inference of phylogenies, there was little "unnecessary shouting" that I recall -- Paul was quite interested in the contrasts work, and by 1990 he and Mark Pagel were actively pushing phylogenetic comparative methods. (It's taking a lot longer to wean physiologists of two-species comparisons, but I have not had to do any of that advocacy -- others have borne the brunt.) J.F. Joe Felsenstein j...@gs.washington.edu Department of Genome Sciences and Department of Biology, University of Washington, Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
When I wrote >> One could argue that your characters are not defined using a >> phylogenetic criterion; that is, when performing a phylogenetic >> analysis (either by ML or Parsimony), you have to assume that your >> dataset is made of homology hypotheses. That is, one could argue that >> your data are based on similarity relationships rather than on >> hypotheses of historical transformations. >> Having this in mind, it is questionable whether, using these data, any >> method could produce an acceptable estimate of the phylogeny of your >> group of interest. Joe Felsenstein responded- > If one simply measures the same character in different species, > is that not good enough? I would say "yes", always that the character of interest could be traced back to a trait present in the oldest common ancestor of these species, and assuming that this ancestral trait evolved into the structures that were measured in the ancient species. Otherwise we would be comparing apples (fruits) with potatoes (roots), much as if we homologate a fly fly with a bat fly: they could be SIMILAR in a given context, but certainly they are not the same thing. > My curiousity is because I suspect that > if Stephane had coded his characters 0/1 before trying to analyze > them, they would then be accepted as "made of homology hypotheses". I'm not against Elsa and Stephan's strategy. As a matter of fact, I do accept, and consider very promising, their approach. I only say that there is a potential problem in determinig character states based _solely_ on similarity. That is why I have harangued for adhering to the philosophical principles that guide our methods: Phylogeny estimates should be based in homology hypotheses, not in similarity. This is true for "cladists" and "probabilists" as well (and please note that I'm quite eclectic regarding these two schools). In summary: If Elsa and Stephan would have assigned 0 to "fly absence" and 1 to "fly presence" and then they have recorded this "character" for flies and bats, I would have taken the same position (and I also would have criticized the use of "absent" as a character state, but this is a different problem...). L > J.F. > > Joe Felsenstein j...@gs.washington.edu > Department of Genome Sciences and Department of Biology, > University of Washington, Box 355065, Seattle, WA 98195-5065 USA > -- Leandro R. Jones, Ph.D. http://www.efpu.org.ar "... To use a computer implies abandoning all techniques developed before to the advent of automated calculation, I say techniques, not sciences..." (J. P. Benzecri) ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
One more comment on all of this. From the standpoint of "comparative methods,"
some similar things have occurred. In particular, the early attempts to take
evolutionary relationships into account when performing statistical analyses
that compared, say, brain size, were always taxonomic, in that Class, Order,
Family, etc. might be taken into account. This was done without much thought
given to whether the classification used was or was not very well tied to
evolutionary (phylogenetic) relationships for the particular group under study.
As my colleagues and I have written, the first "fully phylogenetic" comparative
method was Felsenstein's (1985) independent contrasts. By "fully
phylogenetic," I mean that it could use any specified topology (branching
order) and set of branch lengths, along with an assumed Brownian-motion like
model of trait evolution. This was a huge advance, for several reasons. For
example, at least under older taxonomic schemes, named groups at a given level
(e.g., different families of birds) were never likely to be very comparable in
terms of age -- and hence expected amount of phenotypic variance among species.
Anyway, it took a long time, and perhaps some "unnecessary shouting," to
convince practitioners that *phylogenetic* comparative methods are
fundamentally different from those that are only based on taxonomy, which can
never convey as much information as a detailed (and accurate!) phylogenetic
tree.
Cheers,
Ted
Theodore Garland, Jr., Ph.D.
Professor
Department of Biology
University of California
Riverside, CA 92521
Phone: (951) 827-3524 = Ted's office (with answering machine)
Phone: (951) 827-5724 = Ted's lab
Phone: (951) 827-5903 = Dept. office
Home Phone: (951) 328-0820
FAX: (951) 827-4286 = Dept. office
Email: tgarl...@ucr.edu
http://biology.ucr.edu/people/faculty/Garland.html
List of all publications with PDF files:
http://biology.ucr.edu/people/faculty/Garland/GarlandPublications.html
Garland, T., Jr., and M. R. Rose, eds. 2009. Experimental evolution: concepts,
methods, and applications of selection experiments. University of California
Press, Berkeley, California.
http://www.ucpress.edu/books/pages/10604.php
Associate Director
Network for Experimental Research on Evolution
http://nere.bio.uci.edu/
(A University of California Multicampus Research Project)
Original message
Date: Tue, 29 Sep 2009 11:30:23 -0700
From: Wayne Maddison
Subject: Re: [R-sig-phylo] is maximum likeyhood a
phylogenetic approach?
To: r-sig-phylo@r-project.org
>If you want some real fun, sign on to the Taxacom mailing
list and
>post an opinion about whether a particular method is
"cladistic" or
>not.
>
>But the heated exchange that might result is already
anachronistic.
>There's an expression in English, "It's all over but the
shouting."
>The shouting will go on for some time, but it's over.
Whether or not
>you agree with it, the matter's settled: the community
now very much
>considers that an organism's identity arises from its
genetic
>history, and that classification should as directly as
possible
>reflect that genetic history. Classification is about
words, and it
>helps very much to have the words we use reflect the
concepts that we
>think matter.
>
>Yes, the questions of evolutionary history and
classifications can be
>separated, but I wouldn't say that a confusion between
them hampered
>the progress of evolutionary biology. A battle *within*
evolutionary
>biology between older and newer paradigms as to what
emphasis
>mattered (adaptive zones versus genetic history) was
fought with
>classification as the prize to be won. The fact that most
adherents
>to the new paradigm weren't concerned about
classification, and many
>of the traditionalists were, made it seem to the younger
generations
>as if progress was being hindered by a focus on
classification. Of
>course, since the battle was won long before the shouting
stopped,
>it's understandable why the younger generations felt
burdened by the
>unnecessary shouting.
>
>Wayne
>
>
>At 10:43 AM -0700 29.9.2009, Joe Felsenstein wrote:
>>When I wrote:
>>
>>> >As what classifications should be, or whether methods
should be
>>> >considered as making phylogenetic or phenetic
classifications, I have my
>>> >own position, that no one else seems to back (in
public, anyway). I
>>> >think that we should not think of these trees as
classifications, and not
>>> >call
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Nicely summarized! Cheers, Ted Original message Date: Tue, 29 Sep 2009 11:30:23 -0700 From: Wayne Maddison Subject: Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach? To: r-sig-phylo@r-project.org >If you want some real fun, sign on to the Taxacom mailing list and >post an opinion about whether a particular method is "cladistic" or >not. > >But the heated exchange that might result is already anachronistic. >There's an expression in English, "It's all over but the shouting." >The shouting will go on for some time, but it's over. Whether or not >you agree with it, the matter's settled: the community now very much >considers that an organism's identity arises from its genetic >history, and that classification should as directly as possible >reflect that genetic history. Classification is about words, and it >helps very much to have the words we use reflect the concepts that we >think matter. > >Yes, the questions of evolutionary history and classifications can be >separated, but I wouldn't say that a confusion between them hampered >the progress of evolutionary biology. A battle *within* evolutionary >biology between older and newer paradigms as to what emphasis >mattered (adaptive zones versus genetic history) was fought with >classification as the prize to be won. The fact that most adherents >to the new paradigm weren't concerned about classification, and many >of the traditionalists were, made it seem to the younger generations >as if progress was being hindered by a focus on classification. Of >course, since the battle was won long before the shouting stopped, >it's understandable why the younger generations felt burdened by the >unnecessary shouting. > >Wayne > > >At 10:43 AM -0700 29.9.2009, Joe Felsenstein wrote: >>When I wrote: >> >>> >As what classifications should be, or whether methods should be >>> >considered as making phylogenetic or phenetic classifications, I have my >>> >own position, that no one else seems to back (in public, anyway). I >>> >think that we should not think of these trees as classifications, and not >>> >call them phylogenetic classifications or phenetic classifications, but >>> >consider them as estimates of the phylogeny. The issue of how to classify >>> >is less important anyway. >> >>Emmanuel Paradis responded - >> >>> I have the strong feeling that most users of R and its [phylo]genetics >>> packages are interested in the study of evolutionary processes, not in >>> classification (I rarely see questions about classification or >>> systematics here). So maybe most of us silently back Joe's position. >>> >>> About the issue of how to classify, I think it is very important. The >>> point here is, in my view, that the confusion between classification and >>> evolution greatly hampered the progress of evolutionary biology, but the >>> situation has improved in recent years. >> >>I can't speak for most users of R, but I do suspect that Emmanuel is >>right in that there is agreement with this position among many younger >>evolutionary biologists. But it is a sufficiently intimidating atmosphere >>for them that they do not usually say that out loud. I have stuck my neck >>out, mostly for the fun of it. The reactions among many systematists have >>been strong -- they are really outraged, and figure that this is just >>some arbitrary opinion of mine, which they are (barely) willing to tolerate. >>I suppose the matter will become one of open discussion some day. >> >>Anyway, back to R. >> >>J.F. >> >>Joe Felsenstein j...@gs.washington.edu >> Department of Genome Sciences and Department of Biology, >> University of Washington, Box 355065, Seattle, WA 98195-5065 USA >> >>___ >>R-sig-phylo mailing list >>R-sig-phylo@r-project.org >>https://stat.ethz.ch/mailman/listinfo/r-sig-phylo > > >-- > >Wayne Maddison > Professor and Can
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
When I wrote: > >As what classifications should be, or whether methods should be > >considered as making phylogenetic or phenetic classifications, I have my > >own position, that no one else seems to back (in public, anyway). I > >think that we should not think of these trees as classifications, and not > >call them phylogenetic classifications or phenetic classifications, but > >consider them as estimates of the phylogeny. The issue of how to classify > >is less important anyway. Emmanuel Paradis responded - > I have the strong feeling that most users of R and its [phylo]genetics > packages are interested in the study of evolutionary processes, not in > classification (I rarely see questions about classification or > systematics here). So maybe most of us silently back Joe's position. > > About the issue of how to classify, I think it is very important. The > point here is, in my view, that the confusion between classification and > evolution greatly hampered the progress of evolutionary biology, but the > situation has improved in recent years. I can't speak for most users of R, but I do suspect that Emmanuel is right in that there is agreement with this position among many younger evolutionary biologists. But it is a sufficiently intimidating atmosphere for them that they do not usually say that out loud. I have stuck my neck out, mostly for the fun of it. The reactions among many systematists have been strong -- they are really outraged, and figure that this is just some arbitrary opinion of mine, which they are (barely) willing to tolerate. I suppose the matter will become one of open discussion some day. Anyway, back to R. J.F. Joe Felsenstein j...@gs.washington.edu Department of Genome Sciences and Department of Biology, University of Washington, Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Leandro Jones replied to Stephane Bouee: > One could argue that your characters are not defined using a > phylogenetic criterion; that is, when performing a phylogenetic > analysis (either by ML or Parsimony), you have to assume that your > dataset is made of homology hypotheses. That is, one could argue that > your data are based on similarity relationships rather than on > hypotheses of historical transformations. > Having this in mind, it is questionable whether, using these data, any > method could produce an acceptable estimate of the phylogeny of your > group of interest. If one simply measures the same character in different species, is that not good enough? My curiousity is because I suspect that if Stephane had coded his characters 0/1 before trying to analyze them, they would then be accepted as "made of homology hypotheses". J.F. Joe Felsenstein j...@gs.washington.edu Department of Genome Sciences and Department of Biology, University of Washington, Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Joe Felsenstein wrote on 26/09/2009 21:48: Elsa et Stéphane Bouee wrote: I am currently doing a classification analysis on morphologic data using modern methods of morphometry (procruste analysis). The variables obtained are quantitative and I would like to use them in a phylogenetic approach. For this purpose I used 2 methods: 1) maximum likelihood with the software phylips and its contml add on; As the author of Contml, which is a program, not an "add-on" (whatever that means) I can perhaps comment. 2) cladistic analysis on quantitative variables, with the software TNT developed by Goloboff, Farris and Nixon. I am wondering if the max likelihood is really performing a phylogenetic classification or if it is rather a kind of phenetic method. Maybe the answer may vary according to whom I ask the question …? I have submitted an article presenting the max likelihood as a phylogenetic classification but the reviewers are challenging this assertion. Good luck with the reviewers -- I have never been able to influence people who had strong views about parsimony being better than everything else. There's nothing wrong with the Procrustes superposition. But the assumptions of Contml are that each coordinate is independently changing according to a Brownian motion process, and all at the same rate. This is a dubious assumption at best. I have written about this and warned about this for years (Amer J Human Genetics 1973; Evolution 1981; Annual Review of Ecology and Systematics 1988; article in volume on Morphology, Shape, and Phylogenetics 2002). I have an extensive discussion of the issue in my 2004 book, chapter 24. In PHYLIP the documentation file contchars.html discusses it too. Ideally it would be best to have some estimate of the covariation between the characters, and use that to transform your coordinates to independence. I don't know an easy way to do that unless you have a known phylogeny and can estimate the covariances along it using comparative methods software. So the referees are right to be skeptical, but they should be equally skeptical of discrete characters parsimony approaches which make quite similar assumptions. The hardest-core cladistics people do not admit this. As what classifications should be, or whether methods should be considered as making phylogenetic or phenetic classifications, I have my own position, that no one else seems to back (in public, anyway). I think that we should not think of these trees as classifications, and not call them phylogenetic classifications or phenetic classifications, but consider them as estimates of the phylogeny. The issue of how to classify is less important anyway. I have the strong feeling that most users of R and its [phylo]genetics packages are interested in the study of evolutionary processes, not in classification (I rarely see questions about classification or systematics here). So maybe most of us silently back Joe's position. About the issue of how to classify, I think it is very important. The point here is, in my view, that the confusion between classification and evolution greatly hampered the progress of evolutionary biology, but the situation has improved in recent years. Emmanuel J.F. Joe Felsenstein, j...@gs.washington.edu Dept. of Genome Sciences, Univ. of Washington Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo -- Emmanuel Paradis IRD, Montpellier, France ph: +33 (0)4 67 16 64 47 fax: +33 (0)4 67 16 64 40 http://ape.mpl.ird.fr/ ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Dear Stéphane, One could argue that your characters are not defined using a phylogenetic criterion; that is, when performing a phylogenetic analysis (either by ML or Parsimony), you have to assume that your dataset is made of homology hypotheses. That is, one could argue that your data are based on similarity relationships rather than on hypotheses of historical transformations. Having this in mind, it is questionable whether, using these data, any method could produce an acceptable estimate of the phylogeny of your group of interest. Perhaps you could use the (phylogenetic) fit of your characters as an argument in favour of your approach: in essence, if your characters constitute good homology hypotheses then I would expect them to behave similarly to traditional characters. Furthermore, have you checked if your characters are taxon-dependant? If this is the case, have you checked congruence between estimates of the phylogeny obtained from different sets of taxa? As for your original question, I think that if your evidence is adequate any method will produce an acceptable estimate of the phylogeny. Which is the reviewers’ argument against Contml? Do they prefer the TNT approach? why? Hope it helps. Leandro Jones 2009/9/26 Elsa et Stéphane BOUEE : > Dear phylogeneticists > > > > I am currently doing a classification analysis on morphologic data using > modern methods of morphometry (procruste analysis). > > The variables obtained are quantitative and I would like to use them in a > phylogenetic approach. > > For this purpose I used 2 methods: > > 1) maximum likelihood with the software phylips and its contml add on; > > 2) cladistic analysis on quantitative variables, with the software TNT > developed by Goloboff, Farris and Nixon. > > I am wondering if the max likelihood is really performing a phylogenetic > classification or if it is rather a kind of phenetic method. Maybe the > answer may vary according to whom I ask the question …? > > I have submitted an article presenting the max likelihood as a phylogenetic > classification but the reviewers are challenging this assertion. > > Thank you for your answers > > Stéphane BOUEE, MNHN, France > > > > > [[alternative HTML version deleted]] > > > ___ > R-sig-phylo mailing list > R-sig-phylo@r-project.org > https://stat.ethz.ch/mailman/listinfo/r-sig-phylo > > -- Leandro R. Jones, Ph.D. http://www.efpu.org.ar "... To use a computer implies abandoning all techniques developed before to the advent of automated calculation, I say techniques, not sciences..." (J. P. Benzecri) ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
Re: [R-sig-phylo] is maximum likeyhood a phylogenetic approach?
Elsa et Stéphane Bouee wrote: I am currently doing a classification analysis on morphologic data using modern methods of morphometry (procruste analysis). The variables obtained are quantitative and I would like to use them in a phylogenetic approach. For this purpose I used 2 methods: 1) maximum likelihood with the software phylips and its contml add on; As the author of Contml, which is a program, not an "add- on" (whatever that means) I can perhaps comment. 2) cladistic analysis on quantitative variables, with the software TNT developed by Goloboff, Farris and Nixon. I am wondering if the max likelihood is really performing a phylogenetic classification or if it is rather a kind of phenetic method. Maybe the answer may vary according to whom I ask the question …? I have submitted an article presenting the max likelihood as a phylogenetic classification but the reviewers are challenging this assertion. Good luck with the reviewers -- I have never been able to influence people who had strong views about parsimony being better than everything else. There's nothing wrong with the Procrustes superposition. But the assumptions of Contml are that each coordinate is independently changing according to a Brownian motion process, and all at the same rate. This is a dubious assumption at best. I have written about this and warned about this for years (Amer J Human Genetics 1973; Evolution 1981; Annual Review of Ecology and Systematics 1988; article in volume on Morphology, Shape, and Phylogenetics 2002). I have an extensive discussion of the issue in my 2004 book, chapter 24. In PHYLIP the documentation file contchars.html discusses it too. Ideally it would be best to have some estimate of the covariation between the characters, and use that to transform your coordinates to independence. I don't know an easy way to do that unless you have a known phylogeny and can estimate the covariances along it using comparative methods software. So the referees are right to be skeptical, but they should be equally skeptical of discrete characters parsimony approaches which make quite similar assumptions. The hardest-core cladistics people do not admit this. As what classifications should be, or whether methods should be considered as making phylogenetic or phenetic classifications, I have my own position, that no one else seems to back (in public, anyway). I think that we should not think of these trees as classifications, and not call them phylogenetic classifications or phenetic classifications, but consider them as estimates of the phylogeny. The issue of how to classify is less important anyway. J.F. Joe Felsenstein, j...@gs.washington.edu Dept. of Genome Sciences, Univ. of Washington Box 355065, Seattle, WA 98195-5065 USA ___ R-sig-phylo mailing list R-sig-phylo@r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-phylo
