RE: CSosteoporosis Part 2
My original post was too long. Here is the last part. - Steve N Zinc oxide: Zinc oxide has been shown to increase IGF-1 both as an oral and topical application. Zinc oxide is considered safe except when inhaled: http://www.osha.gov/SLTC/healthguidelines/zincoxide/recognition.html Topical: http://www.ncbi.nlm.nih.gov/pubmed/7899834 http://www.podiatrytoday.com/article/1894 In another recent study, zinc oxide was found to promote epithelialization of full thickness skin wounds by the activation of zinc-dependent MMPs, which facilitate keratinocyte migration. The study also demonstrated that zinc oxide augmented endogenous expression of insulin-like growth factor (IGF-1), which is fundamental in the production of granulation tissue.1 Oral: http://jn.nutrition.org/cgi/content/full/136/7/1786 Protein, milk and coffee: http://www.2-bodybuilding.com/articles/1849-increase_igf-1_levels_natura lly.html Recent studies in adult humans have consistently shown that high milk consumption is associated with a 10 percent to 20 percent increase in circulating IGF-1 levels in humans.10, 19-23 Even more interesting is that a head-to-head study comparing milk to meat as a protein source has shown that milk increases IGF-1 more profoundly than meat proteins. Before I dive into the research, here is a brief summary of IGF-1 basics and why increasing IGF-1 levels are important for increasing muscle mass. IGF-1: Anabolic And Anti-Catabolic A number of studies have associated age-related declines in circulating anabolic factors, including IGF-1 and testosterone, with the muscle atrophy of aging, suggesting that these serum factors are important for the maintenance of muscle mass. Scientists wanted to see what would happen to muscle satellite cells of older mice if they restored their serum levels of IGF-1 to those of young mice. Using a parabiosis model (a parabiosis model surgically attaches the circulatory system of two animals in this case, an older and a younger mouse), these researchers showed that the circulating IGF-1 plays an important role in the regenerative capabilities of skeletal muscle, including satellite cell recruitment, as regenerative capacity was restored in aged mice provided a young circulation.33 This study clearly shows that satellite cells of aging muscle are influenced by serum levels of IGF-1, as chronic exposure to serum from young animals restored the regenerative capacities of satellite cells in old mice. Furthermore, exogenous IGF-1 applied to atrophied muscles in rats has been shown to significantly increase muscle mass and satellite cell activity. Protein Influences IGF-1 Concentrations Concentrations of IGF-1 appear to be influenced by total calories, protein intake and certain micronutrients (potassium, magnesium and zinc), as shown in both animal and human studies.3 It has been reported that the nutritional status, not only energy and amino acid restriction, are critical regulators of IGF-1. For example, one study examined the effect of protein or carbohydrate supplementation in conjunction with strength and conditioning training on IGF-1 over a six-month period. The results of this study indicated that a protein supplement consumed during a strength and conditioning program led to an increase in plasma concentrations of IGF-1 in those subjects compared with the concentrations in a group of persons who also trained, but consumed a calorically equivalent carbohydrate supplement.27 Endurance runners represent the perfect diet model for how diet modifies IGF-1. Endurance runners who consume a diet low in protein yet high in carbohydrates have lower IGF-1 levels compared to sedentary adults consuming a Western diet, which was high in protein and calories.15 This in conjunction with other studies that have also found a substantial depressing effect of a persistently used low-protein diet on circulating total and free IGF-1. A certain amount of protein and carbohydrates are needed for IGF-1, but the traditional high-protein/low-carbohydrate diet bodybuilders follow causes a drop in serum levels of IGF-1 and insulin; however, muscle gene expression of IGF-1 actually increases.34 Got IGF-1? Most bodybuilders know that milk contains casein and is known as a slow protein for its unique ability to coagulate in the small intestines and release slowly into the bloodstream. Approximately 80 percent of the protein in cows milk is casein and the remaining 20 percent is whey. Casein proteins clot in low-pH solutions. Hence, the acidity in the stomach makes casein clump into a gel, whereas whey remains soluble. Both whey and casein contain specific proteins and peptides that may have growth-stimulating effects. Additionally, the degradation of milk proteins when they are exposed to the acid in the stomach results in many other peptides that also may have specific effects. Casein May Protect IGF-1 Degradation More than just proteins, milk contains many other growth-enhancing components. Milk
Re: CSosteoporosis Part 2
Thanks alot for all the info, I'm going thru it now...Kathy - Original Message - From: Norton, Steve stephen.nor...@ngc.com To: silver-list@eskimo.com Sent: Thursday, June 17, 2010 4:06 PM Subject: RE: CSosteoporosis Part 2 My original post was too long. Here is the last part. - Steve N Zinc oxide: Zinc oxide has been shown to increase IGF-1 both as an oral and topical application. Zinc oxide is considered safe except when inhaled: http://www.osha.gov/SLTC/healthguidelines/zincoxide/recognition.html Topical: http://www.ncbi.nlm.nih.gov/pubmed/7899834 http://www.podiatrytoday.com/article/1894 In another recent study, zinc oxide was found to promote epithelialization of full thickness skin wounds by the activation of zinc-dependent MMPs, which facilitate keratinocyte migration. The study also demonstrated that zinc oxide augmented endogenous expression of insulin-like growth factor (IGF-1), which is fundamental in the production of granulation tissue.1 Oral: http://jn.nutrition.org/cgi/content/full/136/7/1786 Protein, milk and coffee: http://www.2-bodybuilding.com/articles/1849-increase_igf-1_levels_natura lly.html Recent studies in adult humans have consistently shown that high milk consumption is associated with a 10 percent to 20 percent increase in circulating IGF-1 levels in humans.10, 19-23 Even more interesting is that a head-to-head study comparing milk to meat as a protein source has shown that milk increases IGF-1 more profoundly than meat proteins. Before I dive into the research, here is a brief summary of IGF-1 basics and why increasing IGF-1 levels are important for increasing muscle mass. IGF-1: Anabolic And Anti-Catabolic A number of studies have associated age-related declines in circulating anabolic factors, including IGF-1 and testosterone, with the muscle atrophy of aging, suggesting that these serum factors are important for the maintenance of muscle mass. Scientists wanted to see what would happen to muscle satellite cells of older mice if they restored their serum levels of IGF-1 to those of young mice. Using a parabiosis model (a parabiosis model surgically attaches the circulatory system of two animals in this case, an older and a younger mouse), these researchers showed that the circulating IGF-1 plays an important role in the regenerative capabilities of skeletal muscle, including satellite cell recruitment, as regenerative capacity was restored in aged mice provided a young circulation.33 This study clearly shows that satellite cells of aging muscle are influenced by serum levels of IGF-1, as chronic exposure to serum from young animals restored the regenerative capacities of satellite cells in old mice. Furthermore, exogenous IGF-1 applied to atrophied muscles in rats has been shown to significantly increase muscle mass and satellite cell activity. Protein Influences IGF-1 Concentrations Concentrations of IGF-1 appear to be influenced by total calories, protein intake and certain micronutrients (potassium, magnesium and zinc), as shown in both animal and human studies.3 It has been reported that the nutritional status, not only energy and amino acid restriction, are critical regulators of IGF-1. For example, one study examined the effect of protein or carbohydrate supplementation in conjunction with strength and conditioning training on IGF-1 over a six-month period. The results of this study indicated that a protein supplement consumed during a strength and conditioning program led to an increase in plasma concentrations of IGF-1 in those subjects compared with the concentrations in a group of persons who also trained, but consumed a calorically equivalent carbohydrate supplement.27 Endurance runners represent the perfect diet model for how diet modifies IGF-1. Endurance runners who consume a diet low in protein yet high in carbohydrates have lower IGF-1 levels compared to sedentary adults consuming a Western diet, which was high in protein and calories.15 This in conjunction with other studies that have also found a substantial depressing effect of a persistently used low-protein diet on circulating total and free IGF-1. A certain amount of protein and carbohydrates are needed for IGF-1, but the traditional high-protein/low-carbohydrate diet bodybuilders follow causes a drop in serum levels of IGF-1 and insulin; however, muscle gene expression of IGF-1 actually increases.34 Got IGF-1? Most bodybuilders know that milk contains casein and is known as a slow protein for its unique ability to coagulate in the small intestines and release slowly into the bloodstream. Approximately 80 percent of the protein in cows milk is casein and the remaining 20 percent is whey. Casein proteins clot in low-pH solutions. Hence, the acidity in the stomach makes casein clump into a gel, whereas whey remains soluble. Both whey and casein contain specific proteins and peptides that may have growth-stimulating effects. Additionally, the degradation of milk
