[cbdnet.access.gpo.gov] PART: U.S. GOVERNMENT PROCUREMENTS SUBPART: SERVICES CLASSCOD: A--Research and Development OFFADD: National Technology Transfer Center, Wheeling Jesuit University, 316 Washington Ave., Wheeling, WV 26003-6295 SUBJECT: A--RESEARCH & DEVELOPMENT -- THE SUBJECT TECHNOLOGY IS A SET OF FOUR COMPOUNDS THAT APPEARS TO BE USEFUL IN ALLEVIATING THE TOXIC EFFECTS OF ACETALDEHYDE (ACH). ACH, THE FIRST METABOLIC PRODUCT OF INGESTED ETHANOL (ETHYL ALCOHOL), IS KNOWN TO EXHIBIT LIVER TOXICITY AND IS SUSPECTED IN THE ETIOLOGY SOL #99-071 DUE 122001 POC Mr. William Chard at 1-800-678-6882 or (304) 243-2039. DESC: N-Terminal Dipeptides of D (-) Penicillamine as Sequestration Agents for Aldehydes ----------The Department of Veterans Affairs (VA), through the National Technology Transfer Center (NTTC), is seeking a commercialization partner to further develop this technology through a Cooperative Research and Development Agreement (CRADA).---------The subject technology is a set of four compounds that appears to be useful in alleviating the toxic effects of acetaldehyde (AcH). AcH, the first metabolic product of ingested ethanol (ethyl alcohol), is known to exhibit liver toxicity and is suspected in the etiology of alcoholic liver disease. There is reason to believe that these compounds may work as sequestration agents for aldehydes generally, including formaldehyde (the first metabolic product of methanol) and glutaraldehyde, as well as AcH. On this basis, it is hypothesized that any one or more of these compounds are candidates for use as an antidote against the toxic effects of AcH, formaldehyde and glutaraldehyde, and thus may be effective both in treatment of chronic alcoholism and in cases of acute alcohol or aldehyde poisoning. A secondary effect may be the reduction of the offensive body odor produced by unsaturated aldehydes. LINKURL: www.nttc.edu LINKDESC: Click here to find out additional information regarding this technology EMAILADD: [EMAIL PROTECTED] EMAILDESC: click here to contact the contracting officer via e-mail CITE: (W-317 SN5128W9)
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