Re: [tips] Placebos getting stronger?

2009-08-30 Thread michael sylvester
Christopher DI could hardly differentiate between a glass of cream soda and one 
that supposedly contained Canadian whiskey.

Michael


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Re: [tips] Placebos getting stronger?

2009-08-30 Thread Paul Brandon
Sounds like you've been drinking too much -- habituated to ethanol.

On Aug 30, 2009, at 11:19 AM, michael sylvester wrote:


 I could hardly differentiate between a glass of cream soda and one  
 that supposedly contained Canadian whiskey.

Paul Brandon
Emeritus Professor of Psychology
Minnesota State University, Mankato
paul.bran...@mnsu.edu


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Re: [tips] Placebos getting stronger?

2009-08-29 Thread Christopher D. Green
Frantz, Sue wrote:


 Through the Improbable Research blog comes this article from Wired, 
 Placebos Are Getting More Effective. Drugmakers Are Desperate to Know 
 Why.  
 http://www.wired.com/medtech/drugs/magazine/17-09/ff_placebo_effect?currentPage=all
  
 **

  

 An excerpt:

 Some products that have been on the market for decades, like Prozac, 
 are faltering in more recent follow-up tests. In many cases, these are 
 the compounds that, in the late '90s, made Big Pharma more profitable 
 than Big Oil. But if these same drugs were vetted now, the FDA might 
 not approve some of them.


I doubt that the FDA wouldn't approve them. The FDA hasn't been very 
independent for a very long time. Nevertheless, I recall reading years 
ago that there never were any double-blind clinical trials on Prozac 
that are worthy of the name. Apparently the side effects of Prozac are 
so pronounced in so many people that the vast majority of the 
experimental subjects were well aware that they were on the drug 
virtually from the outset. Placebo effects ensued rapidly.

Regards,
Chris
-- 

Christopher D. Green
Department of Psychology
York University
Toronto, ON M3J 1P3
Canada

 

416-736-2100 ex. 66164
chri...@yorku.ca
http://www.yorku.ca/christo/

==


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Re: [tips] Placebos getting stronger?

2009-08-25 Thread David Epstein

On Tue, 25 Aug 2009, Sue Frantz quoted _Wired_:


the so-called effect size (a measure of statistical significance)


Ouch.

_Wired_ is often really interesting, but I've found that you have to
double-check most of what they say about science.

--David Epstein
  da...@neverdave.com

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RE:[tips] Placebos getting stronger?

2009-08-25 Thread Marc Carter
Not really apropos, but interesting (to me, anyway).  Someone (I forgot who; 
I'm sorry) said once that the entire history of medicine before 1900 is a 
history of the placebo effect.  I think it's a bit of an exaggeration, but 
just a bit.

m


--
Marc Carter, PhD
Associate Professor and Chair
Department of Psychology
College of Arts  Sciences
Baker University
--






From: Frantz, Sue [mailto:sfra...@highline.edu]
Sent: Tuesday, August 25, 2009 12:22 PM
To: Teaching in the Psychological Sciences (TIPS)
Subject: [tips] Placebos getting stronger?




Through the Improbable Research blog comes this article from Wired, 
Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why.  
http://www.wired.com/medtech/drugs/magazine/17-09/ff_placebo_effect?currentPage=all



An excerpt:

Some products that have been on the market for decades, like Prozac, 
are faltering in more recent follow-up tests. In many cases, these are the 
compounds that, in the late '90s, made Big Pharma more profitable than Big Oil. 
But if these same drugs were vetted now, the FDA might not approve some of 
them. Two comprehensive analyses of antidepressant trials have uncovered a 
dramatic increase in placebo response since the 1980s. One estimated that the 
so-called effect size (a measure of statistical significance) in placebo groups 
had nearly doubled over that time.

It's not that the old meds are getting weaker, drug developers say. 
It's as if the placebo effect is somehow getting stronger.

Additionally the article provides a nice history and overview of the 
modern placebo effect as well as some current applications, such as this 
(ethically suspect) one.



One recent afternoon in [Fabrizio Benedetti's] lab [at the University 
of Turin], a young soccer player grimaced with exertion while doing leg curls 
on a weight machine. Benedetti and his colleagues were exploring the potential 
of using Pavlovian conditioning to give athletes a competitive edge 
undetectable by anti-doping authorities. A player would receive doses of a 
performance-enhancing drug for weeks and then a jolt of placebo just before 
competition.





--
Sue Frantz http://flightline.highline.edu/sfrantz/
  Highline Community College
Psychology, CoordinatorDes Moines, WA
206.878.3710 x3404  sfra...@highline.edu 
mailto:sfra...@highline.edu

Office of Teaching Resources in Psychology, Associate Director

Project Syllabus http://teachpsych.org/otrp/syllabi/syllabi.php

APA Division 2: Society for the Teaching of Psychology 
http://teachpsych.org/otrp/syllabi/syllabi.php



APA's p...@cc Committee http://www.apa.org/ed/pcue/ptatcchome.html






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