I'm having the same issue using this server layoyut, which worked in 9.10:
Screen Bottom Screen
Screen Middle Screen Above Bottom Screen
Screen Left Screen LeftOf Left Screen
Screen Right Screen RightOf Right Screen
Unfortunatly I can't work around it as I need Bottom Screen to be
screen 0. Everything thing is fine if I assign the screens from left to
right, top to bottom.
The bug was reported to xorg, and there are two patches. They stop the
crash but my pointer is confined to screen 0 when using them.
https://bugs.freedesktop.org/show_bug.cgi?id=24986
** Bug watch added: freedesktop.org Bugzilla #24986
http://bugs.freedesktop.org/show_bug.cgi?id=24986
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Multi-Screen Layout (3) - Moving Mouse to Left Screen Causes Segmentation Fault
https://bugs.launchpad.net/bugs/551202
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