Hi Michael,
Sorry for the very late reply.
As you probably know most methods infer regions of LOH using Hidden
Markov Models on genotype calls. In terms of software, you are
probably aware of dChipSNP, which is certainly a good candidate. I am
not sure whether Birdsuite from the Broad explicitly
Hi Pierre,
thanks for the offer. In the one project, we are looking into genetic
causes for Silver-Russel syndrome. So far, we have identified only few
recurring CNAs. However, one goal is to screen patients for UPDs (that
is, copy number neutral LOH), too; some regions (e.g. chromosome 7)
have b
Hi Michael,
I would be happy to try to help you here, but as Henrik suggested it's
hard to answer without knowing what chip type you are using/planning
to use... Can you be more specific ?
Best,
Pierre.
On Tue, Feb 3, 2009 at 1:38 PM, Henrik Bengtsson wrote:
>
> Hi,
>
> there are no methods o
Hi,
there are no methods of such analysis available in aroma.affymetrix,
and there is no time line for implementing that. It is of course on
our wishlist, though. Note also that "LOH analysis" is rather
unspecific; there are many different ways to infer LOH, of which some
depend on what kind of
