[Bioc-devel] writeVcf performance

2014-08-05 Thread Michael Lawrence
Hi guys (Val, Martin, Herve): Anyone have an itch for optimization? The writeVcf function is currently a bottleneck in our WGS genotyping pipeline. For a typical 50 million row gVCF, it was taking 2.25 hours prior to yesterday's improvements (pasteCollapseRows) that brought it down to about 1

Re: [Bioc-devel] Additional summarizeOverlaps counting modes for ChIP-Seq

2014-08-05 Thread Ryan C. Thompson
Hi Valerie, I got really busy around May and never got a chance to thank you for adding this option to summarizeOverlaps! So thank you! -Ryan On Thu 01 May 2014 04:25:33 PM PDT, Valerie Obenchain wrote: GenomicAlignments 1.1.8 has a 'preprocess.reads' argument. This should be a function

Re: [Bioc-devel] Additional summarizeOverlaps counting modes for ChIP-Seq

2014-08-05 Thread Ryan C. Thompson
Hi again, I'm looking at the examples in the summarizeOverlaps help page here: http://www.bioconductor.org/packages/devel/bioc/manuals/GenomicAlignments/man/GenomicAlignments.pdf And the examples fod preprocess.reads are a little confusing. One of the examples passes some additional ...