Dear all,

I have encountered a very frustrating 'memory not mapped' problem when 
compiling ensembldb package:

>BiocManager::install("ensembldb", ask = FALSE)
Bioconductor version 3.10 (BiocManager 1.30.8), R Under development (unstable)
  (2019-10-15 r77295)
Installing package(s) 'ensembldb'
Warning: unable to access index for repository 
https://bioconductor.org/packages/3.10/bioc/bin/macosx/el-capitan/contrib/4.0:
  cannot open URL 
'https://bioconductor.org/packages/3.10/bioc/bin/macosx/el-capitan/contrib/4.0/PACKAGES'
Warning: unable to access index for repository 
https://bioconductor.org/packages/3.10/data/annotation/bin/macosx/el-capitan/contrib/4.0:
  cannot open URL 
'https://bioconductor.org/packages/3.10/data/annotation/bin/macosx/el-capitan/contrib/4.0/PACKAGES'
Warning: unable to access index for repository 
https://bioconductor.org/packages/3.10/data/experiment/bin/macosx/el-capitan/contrib/4.0:
  cannot open URL 
'https://bioconductor.org/packages/3.10/data/experiment/bin/macosx/el-capitan/contrib/4.0/PACKAGES'
Warning: unable to access index for repository 
https://bioconductor.org/packages/3.10/workflows/bin/macosx/el-capitan/contrib/4.0:
  cannot open URL 
'https://bioconductor.org/packages/3.10/workflows/bin/macosx/el-capitan/contrib/4.0/PACKAGES'
Warning: unable to access index for repository 
https://cran.rstudio.com/bin/macosx/el-capitan/contrib/4.0:
  cannot open URL 
'https://cran.rstudio.com/bin/macosx/el-capitan/contrib/4.0/PACKAGES'
installing the source package ‘ensembldb’

trying URL 
'https://bioconductor.org/packages/3.10/bioc/src/contrib/ensembldb_2.9.6.tar.gz'
Content type 'application/x-gzip' length 3313875 bytes (3.2 MB)
==================================================
downloaded 3.2 MB

* installing *source* package ‘ensembldb’ ...
** using staged installation
** R
** inst
** byte-compile and prepare package for lazy loading
sh: line 1: 11388 Segmentation fault: 11  R_TESTS= 
'/Library/Frameworks/R.framework/Resources/bin/R' --no-save --no-echo 2>&1 < 
'/var/folders/c0/dsy4zf0d75x8wp0w89r8g89nh1q7rl/T//Rtmp2uO8sw/file2c759026e04'

*** caught segfault ***
address 0x2bd90, cause 'memory not mapped'

Traceback:
1: fun(libname, pkgname)
2: doTryCatch(return(expr), name, parentenv, handler)
3: tryCatchOne(expr, names, parentenv, handlers[[1L]])
4: tryCatchList(expr, classes, parentenv, handlers)
5: tryCatch(fun(libname, pkgname), error = identity)
6: runHook(".onLoad", env, package.lib, package)
7: loadNamespace(j <- i[[1L]], c(lib.loc, .libPaths()), versionCheck = vI[[j]])
8: asNamespace(ns)
9: namespaceImportFrom(ns, loadNamespace(j <- i[[1L]], c(lib.loc,     
.libPaths()), versionCheck = vI[[j]]), i[[2L]], from = package)
10: loadNamespace(j <- i[[1L]], c(lib.loc, .libPaths()), versionCheck = vI[[j]])
11: asNamespace(ns)
12: namespaceImportFrom(ns, loadNamespace(j <- i[[1L]], c(lib.loc,     
.libPaths()), versionCheck = vI[[j]]), i[[2L]], from = package)
13: loadNamespace(package, lib.loc)
14: doTryCatch(return(expr), name, parentenv, handler)
15: tryCatchOne(expr, names, parentenv, handlers[[1L]])
16: tryCatchList(expr, classes, parentenv, handlers)
17: tryCatch({    attr(package, "LibPath") <- which.lib.loc    ns <- 
loadNamespace(package, lib.loc)    env <- attachNamespace(ns, pos = pos, deps, 
exclude, include.only)}, error = function(e) {    P <- if (!is.null(cc <- 
conditionCall(e)))         paste(" in", deparse(cc)[1L])    else ""    msg <- 
gettextf("package or namespace load failed for %s%s:\n %s",         
sQuote(package), P, conditionMessage(e))    if (logical.return)         
message(paste("Error:", msg), domain = NA)    else stop(msg, call. = FALSE, 
domain = NA)})
18: library(pkg, character.only = TRUE, logical.return = TRUE, lib.loc = 
lib.loc,     quietly = quietly)
19: .getRequiredPackages2(pkgInfo, quietly, lib.loc, useImports)
20: .getRequiredPackages(quietly = TRUE)
21: withCallingHandlers(expr, packageStartupMessage = function(c) 
invokeRestart("muffleMessage"))
22: suppressPackageStartupMessages(.getRequiredPackages(quietly = TRUE))
An irrecoverable exception occurred. R is aborting now ...
ERROR: lazy loading failed for package ‘ensembldb’
* removing 
‘/Library/Frameworks/R.framework/Versions/4.0/Resources/library/ensembldb’

> sessionInfo()
R Under development (unstable) (2019-10-15 r77295)
Platform: x86_64-apple-darwin15.6.0 (64-bit)
Running under: macOS Mojave 10.14.6

Matrix products: default
BLAS:   
/Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.0.dylib
LAPACK: 
/Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base

other attached packages:
[1] BiocManager_1.30.8

loaded via a namespace (and not attached):
[1] compiler_4.0.0 tools_4.0.0
>

Your insights will be greatly appreciated.

Jack
--
Yuelin Jack Zhu, MD, MS

Bioinformatics Specialist
BG 37 RM 6138
37 CONVENT DR
BETHESDA MD 20814
Phone:  240-760-7439
E-mail: zhuj...@mail.nih.gov



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