[ccp4bb] 2010 Hybrid Methods Meeting Announcement

2009-11-30 Thread Wes Sundquist
Dear Colleagues: My co-organizers and I invite you to attend the 2010 Symposium on Structural Analysis of Supramolecular Assemblies by Hybrid Methods. The Symposium will be held at Granlibakken Conference Center, Lake Tahoe, California, and the dates are March 10-14, 2010. The overall goal of t

[ccp4bb] tutorial / pipeline for refmac refinement

2009-11-30 Thread rui
Hi, Is there any tutorial that describe the refinement procedure with refmac? There are several options, restrained, rigid body, TLS...,I have a crystal has 2 copies in ASU, and currently I'm just using restrained refinement, but wonder if I should also try some other type of refinement too . Than

Re: [ccp4bb] Enzyme inhibitor

2009-11-30 Thread Soisson, Stephen M
You don't give details on the assay, but if it is a fluorescence or colorimetric screen, you might have interference. Is the compound precipitating and/or aggregating? Good luck- Steve -Original Message- From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of Ezra Peisa

Re: [ccp4bb] Enzyme inhibitor

2009-11-30 Thread Ezra Peisach
Sivaraman Padavattan wrote: Dear all, I am performing an assay to screen for the inhibitor molecules. One of our compound shows inhibition at 100 μM and activation at 500μM conc. What could be the possible reason for the compound work differently in two different conc. Thanks Sivaraman

[ccp4bb] Correlative Microscopy Workshop

2009-11-30 Thread elizabeth . duke
Slightly off-topic but there might be some who are interested in the following workshop taking place in Oxford Jan 13-14 2010. http://www.instruct-fp7.eu/index.php?option=com_events&task=view_detail&; agid=80&year=2010&month=01&day=13&Itemid=6 There will be a workshop on Correlative Microscopy