A post-doctoral position is available in the Netherlands Cancer Institute in the group of Titia Sixma. We are searching for an excellent candidate with expertise in protein biochemistry, X-ray crystallography and/or cryo-electron microscopy single particle reconstruction.
We study regulatory processes of ubiquitin conjugation in DNA regulation using in vitro reconstructions and structural methods. We have excellent access to high-end structural facilities such as synchrotrons (ESRF, SLS) and cryo-EM microscopy (NeCEN, Utrecht) and we share equipment with the iNEXT biophysical facility, ensuring high class instruments and support. Equipment includes high throughput crystallization, routine synchrotron access, and excellent biophysics (SPR, stopped-flow, ITC, thermophoresis, MALLS, Optim etc). Topics of the projects center around the role of ubiquitin conjugation in DNA repair and epigenetic regulation. Integration with biology groups studying these themes is excellent, thanks to close proximity to excellent groups in field close by (Leiden, ErasmusMC, NKI) The Netherlands Cancer Institute is a center of excellence with a high standard of biological research and an interactive atmosphere, with shared group meetings and social events. It is located in Amsterdam, with all its cultural amenities, and is close to Schiphol airport. We share meetings and lab-space with the groups of Tassos Perrakis and Robbie Joosten, who are (among other things) interested in method development for structural biology Applicants should write an e-mail with motivation, CV and names of three references to t.si...@nki.nl before August 8. Titia K. Sixma Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam t.si...@nki.nl Tel : +31205121959
