[ccp4bb] MX Positions Available at EMBL Hamburg

2017-03-07 Thread Thomas R. Schneider
Dear all, at EMBL Hamburg two positions are open in the MX-Team. We are looking for: - a Beamline Scientist in Macromolecular Crystallography https://www.embl.de/jobs/searchjobs/index.php?ref=HH_00108 - an Industrial Liaison Scientist in Macromolecular Crystallography

[ccp4bb] Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Highly Structured Viral RNAs

2017-03-07 Thread Jinwei Zhang
A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between

Re: [ccp4bb] [EXTERNAL] Re: [ccp4bb] B-factors/Occupancies Versus "Local Resolution"

2017-03-07 Thread Keller, Jacob
Hi Ian, and thanks for the interesting email. The insect example should be understood in the context of the OED definition of resolution, which uses the word “measureable.” If one has a megapixel image of a blurred-wing insect, the wings are certainly “measureable” in principle, but are in

Re: [ccp4bb] [EXTERNAL] Re: [ccp4bb] B-factors/Occupancies Versus "Local Resolution"

2017-03-07 Thread Ian Tickle
Hi Yong Yes of course the _average_ resolution of the map, whether from single crystal or PD, is determined 'more or less' by the minimum d-spacing ('resolution limit'), in the same way that the _average_ quality of the agreement between the model and the data is related 'more or less' to the R

Re: [ccp4bb] [EXTERNAL] Re: [ccp4bb] B-factors/Occupancies Versus "Local Resolution"

2017-03-07 Thread Yong Wang
Ian, Won’t the spatial resolution of the electron density map be determined more or less by the “resolution” (d-spacing)? While the normal electron density includes model contribution, what about the resolution of the Patterson map? For the case of powder diffraction, after the lines are

Re: [ccp4bb] B-factors/Occupancies Versus "Local Resolution"

2017-03-07 Thread Ian Tickle
Hi Jacob I'm a bit puzzled that you say that what you call 'local resolution' is used 'to model disordered regions' in cryo-EM. AFAIK it does no such thing: resolution is certainly used as a _metric_ of the EM map quality but it's not used for modelling. High resolution EM maps (which I assume

Re: [ccp4bb] Crystallization suggestion for antigen-Fc complex

2017-03-07 Thread Enrico Stura
Ankita, Fc are different from Fabs. Even if glycosylated their solubility is lower. Fc stands for constant fragment but also for Fragment crystallizable: https://en.wikipedia.org/wiki/Fragment_crystallizable_region From its name, they should be easy to crystallize. If you have problems to not

[ccp4bb] Cryo-EM Symposium, 6-7 July 2017, European Photon & Neutron Campus, Grenoble, France

2017-03-07 Thread Montse SOLER LOPEZ
Dear all, We are pleased to announce the Cryo-Electron Microscopy Symposium that will take place from 6-7th July, 2017 in Grenoble, France. The aim of this symposium is to promote the exciting opportunities in structural biology opened by the advances in cryo-electron microscopy and by the

[ccp4bb] Postdoc position @ AstraZeneca, Sweden

2017-03-07 Thread Edman, Karl
Dear all, We're looking for a talented scientist to join the AstraZeneca Post Doc Programme to study the structure and function of a full-length transcription factor in complex with novel ligands and link this information to broader mode of action studies for active clinical projects. You will