Liz Tunbridge's lab at Oxford are offering PCR machines and expertise to
help fill the testing shortfall in the UK (see
https://www.wired.co.uk/article/coronavirus-uk-testing-key-workers). This
is a worthy initiative, if it is accepted (logistics are the main problem).
The structural biology commun
For general interest,
The Francis Crick institute in London is offering facilities to public health
England, and over 300 Crick scientists have volunteered to help with testing.
https://www.crick.ac.uk/news/2020-03-19_francis-crick-institute-offers-assistance-in-emergency-coronavirus-testing
--
Same for Newcastle University, particularly our Faculty of Medical Sciences but
colleagues and labs from across the University.
There are also several efforts to get scientists to help:
http://crowdfightcovid19.org/volunteers
Thanks to all those trying to help!
Paula
On 21 Mar 2020, at 11:5
Dear James,
On Fri, Mar 20, 2020 at 03:59:01PM -0700, James Holton wrote:
> ORF8 has only one homolog in the PDB: 5o32 with 25% identity over a stretch
> of 60 residues. This homologous region contains the S84L site (Val I544 in
> 5o32). I had a quick look and appears to be a cavity-filling muta
The best way against COVID19 is staying at home, staying at home, and
staying at home.
Nothing else.
On Fri, Mar 20, 2020, 5:59 PM James Holton wrote:
> You might think that as a structural biologist you won't be able to do
> much about COVID-19 anytime soon, but that is not true. Yes, real-wo
Begin forwarded message:
From: "charles w carter, jr" mailto:cwcar...@ad.unc.edu>>
Subject: Re: [ccp4bb] CCP4BB vs COVID19
Date: March 21, 2020 at 8:07:53 AM EDT
To: James Holton mailto:jmhol...@lbl.gov>>
Brilliant post, James. Thanks so much!
I also find what you describe interesting, because
James, this isn't conventional structural biology, but may be of interest,
and I haven't been able get any mainstream virologists to think about it.
The protein sequences are obviously of interest, but so are the RNA
sequences at both ends of the Covid genome, which have conserved secondary
struct
Hi James
5o32I is not a homolog of ORF8 - the BLAST e-value is insignificant. In fact,
rather than the EGF-like fold of 5o32I, ORF8 has an Ig-like fold similar to
ORF7 (for which there is a structure; 1xak).
https://toolkit.tuebingen.mpg.de/jobs/2717885_1
I must say I got quite excited seei
In Ascoidea asiatica where CUG is translated as both Leu and Ser.
Mühlhausen S., Schmitt H.D., Pan K.T., Plessmann U., Urlaub H., Hurst L.D.,
Kollmar M. Endogenous stochastic decoding of the CUG codon by competing Ser-
and Leu-tRNAs in Ascoidea asiatica. Curr. Biol. 2018; 28:2046-2057.
Perhaps,
Hi.
I get this "INPUT ERROR: Erro interpreting Composition sequence" message when I
try to MR in ccp4 Pherser MR. I've been using regular *.fasta file for the
sequence. First, I thought the error coming from the changes I made to the
*.fasta fill, but even when I'm using the original file stra
Dear Structure Biologists,
We have some significant expertise in stabilizing the membrane proteins
and domains in different kinds of membranous environments such as
liposomes (small and giant vesicles suitable for biochemical and
electrophysiological analysis), nanodiscs and malic acid based p
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