PhD fellowship at the Faculty of Health and Medical Sciences, University of
Copenhagen
We are offering a three-year PhD fellowship within a project based upon
positive allosteric modulation of kainate receptors (KARs). The employment as
PhD fellow is full time and for 3 years. The PhD fellows
Dear All,
Kindly be informed that new program for analysis and validation of
macromolecular B values named ToBvalid is already available online.
(https://github.com/ToBvalid/tobvalid)
Please find the user guide here:
https://github.com/ToBvalid/tobvalid/blob/master/doc/User_Guide.pdf
Here is
Hi Alan,
I think new AKTA collector can be refrigerated. If this is not an option,
consider putting only collector in the cold cabinet and cooling down the
buffers. Also, you can put only columns and fraction collector inside cabinet
which has side port for such use. Although you will have to us
Dear Matthew,
You seem to have been unlucky with this data collection. STARANISO
would be prepared to see significant data extending to 2.0A along a*, 2.7A
along b*, and 1.7A along c*. The latter limit, however, involves some guess
work via the fitting by an ellipsoid of a cut-off surface tha
hi alan,
why do you want to put the thing in a cold cabinet? if you have protease
problems, there are better ways to get rid of them than exploiting Q10. on the
other hand, you'll increase viscosity and thus slow down the flow rates. also,
the high humidity will reduce the lifetime of your Äkta
Hi Alan
We got one a few years back, from Fisher, although I think Thermo are the
manufacturer's:
Refrigerator FRCR4504W Forma chromatography THERMO SCIENTIFIC FORMA FRCR4504W
They also arranged for a heavy metal shelf to hold the AKTA as the normal
shelves won't hold the weight.
We only have
*Please* dont throw good 1.8A data for the sake of statistics!
You should see more detail along certain directions
You will publish your structure providing honest details of the anisotropy
(I hope..) but it is the map quality that matters ..
Eleanor
On Sun, 21 Jun 2020 at 15:16, Matthew Snee <
ma
Dear All
Many thanks to Johann for the suggestion of Topsearch - rather pleasingly our
tetramer is novel in the tetrameric arrangement, but each of the dimers has its
DNA recognition helices in agreement with several hits 😊a win all round
Bringing joy to my lockdown.
Best
Andy
###
Hi everyone.
I have an x ray structure that I am finishing up, and there are a few ambiguous
regions where the peptide is poorly resolved.
The data is highly anisotrophic, and requires truncation to around 2.4A to
achieve acceptable merging stats, although there is data in the "good"
direction
WEll I would use PISA first to see if the buried surface areaagrees with my
oligamer construction - that uses symmetry..
Then test SSM with the suggested oligamers..
Eleanor
On Sun, 21 Jun 2020 at 10:24, Brandstetter Johann <
johann.brandstet...@sbg.ac.at> wrote:
> Topsearch does that, https://to
Topsearch does that, https://topsearch.services.came.sbg.ac.at/
Best,
Hans
Von: CCP4 bulletin board Im Auftrag von Andrew Lovering
Gesendet: Sonntag, 21. Juni 2020 10:51
An: CCP4BB@JISCMAIL.AC.UK
Betreff: Re: [ccp4bb] Looking for method to find similar oligomeric arrangement
Thanks Boaz for the
Thanks to all of you pointing me towards ProtCID, but unless I'm mistaken this
works only for deposited co-ordinates / PDB entries?
I was more looking for something that would take my (yet to be deposited) PDB
file, with its inherent tetrametric hth fold, and find similar folds in similar
arra
Hi Andy,
Are you familiar with ProtCID?
http://dunbrack2.fccc.edu/ProtCiD/Default.aspx
Might be relevant.
Best,
Orly
On Sun, Jun 21, 2020 at 12:02 AM Andrew Lovering
wrote:
> Dear colleagues,
>
>
> I have a structure of a simple, common fold (hth, dna-binding) that I
> believe has oligomerize
Thanks Boaz for the SSM heads up. I was much too DALI-centric!
One last point, if anyone can offer an opinion - I presume most methods will
match but only within ASU contents.
Does any approach utilize deposited "biological unit" classification or (better
still) crystallographic symmetry oper
Dear All
Apologies for being wildly off topic, but we're trying to find a decent
cold cabinet for 2x AKTA Pure + F9C + sample pump. Does anyone have any
recommendations, especially for sliding door models?
Cheers,
Alan
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