Re: [ccp4bb] Different conformation of chains

Dear Shine.star1609, Your structural observation may be really different from the original one. There are several things to do now: 1. Check whether the same interpretation could be possible in the original structure. Are there maps or the original diffraction data? You could also

Re: [ccp4bb] Different conformation of chains

Hi, if I understood your question correctly, then one of 13 scenarios described here: http://phenix-online.org/phenixwebsite_static/mainsite/files/newsletter/CCN_2015_07.pdf#page=12 fits your situation and you should be able to handle it in refinement all right. For more specific advice please

[ccp4bb] Different conformation of chains

Dear All, I am working with a protein, the structure of which is already published in the PDB (2 chains in asu) The published structure has a break of around 20 residues. I have crystallized the same protein and saw some density near the gap (20 residues break). I could build 3-4 residues in

[ccp4bb] tech and postdoc position at Brown University

Hello: Two positions are available in my lab at Brown University. Please see below and feel free to email me for more information. *POSTDOCTORAL AND TECHNICIAN POSITIONS* *at Brown University, USA* *The Deaconescu Lab* at Brown University has one opening for a postdoctoral researcher and one

[ccp4bb] Research Staff Position at Baylor College of Medicine

STAFF MEMBER / ASSOCIATE A full-time staff position is available in the Advanced Technology Core for Macromolecular X-ray Crystallography at Baylor College of Medicine. The mission of the X-ray core is to assist academic researchers and physician-scientists in finding a structure solution of

[ccp4bb] Protein Purification jobs at UCB (Slough, UK)

Dear all Do you enjoy purifying challenging proteins? Do you want to support antibody and small molecule drug discovery projects to transform patients' lives for the better? Then consider applying for these roles in our Protein Production group: Senior Scientist - Protein Biochemist job in

[ccp4bb] Reminder: CBMS Lecture Series - October 20 - Lee Makowski

Please join us ……….. Molecular Events in the Progression of Alzheimer’s Disease Lee Makowski Northeastern University WEDNESDAY, October 20, 13:30 (EST) Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJIscuqgrD0vG8SVmZ49QwTrS8eGSZrs-1U Abstract:

[ccp4bb] LMB Kendrew Lecture on AlphaFold

Dear all, I thought you might be interested to know that the recent John Kendrew Lectures at the MRC Laboratory of Molecular Biology, given by Demis Hassabis and John Jumper from DeepMind on AI in

[ccp4bb] Postdoctoral position in FBDD in Cambridge UK

Dear colleagues, We have an opening in our group at the Department of Biochemistry, University of Cambridge, for a postdoctoral researcher for 12 months to work on an exciting drug discovery project with Alborada Drug Discovery Institute (https://cambridge-ddi.alzheimersresearchuk.org/) to

[ccp4bb] postdoc position available in the lab of Prof. Eddy Arnold (Rutgers University, NJ, USA)

Dear All, We have an immediate opening for a skilled post-doctoral researcher in the laboratory of Prof. Eddy Arnold at Rutgers University (NJ, USA). The aim of the project is to study the structure and function of human viral proteins, mainly polymerases from HIV-1, SARS-CoV-2 and other RNA

Re: [ccp4bb] am I doing this right?

Hi Kay Can I just confirm that your result Iobs=0.01 sigIobs=0.01 is the estimate of the true average intensity *per pixel* for a patch of 100 pixels? So then the total count for all 100 pixels is 1 with variance also 1, or in general for k observed counts in the patch, expectation = variance =