Dear ccp4 community, Rheos Medicines, a newly formed start-up from Third Rock Ventures, is seeking a structural biologist with industrial experience to join our team. Please reply to the posting below – only inquiries to the posting will be responded to.
https://rheosrx.com/our-workplace/careers/associate-director-structural-biology/<https://rheosrx.com/our-workplace/careers/associate-director-structural-biology/> Sincerely, Brian Title: Associate Director, Structural Biology Department: Drug Discovery Reports To: VP, Drug Discovery Location: Cambridge, MA The Company: At Rheos, we are leading the way in the emerging field of immunometabolism to discover novel medicines to treat inflammatory-mediated diseases, including autoimmune diseases. Our medicines control metabolic pathways of immune cells that influence their activation state, in order to rebalance immune responses that cause inflammation or autoimmunity. The Role: The Associate Director, Structural Biology, will provide leadership and expertise in the structural characterization of Rheos’s drug targets. The ideal candidate will be focused on protein crystallography but will integrate with the drug discovery organization to implement a variety of biophysical techniques. Major Responsibilities: * Collaborate with colleagues in lead discovery, biology, and chemistry to develop a structural biology strategy. * Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols. * Crystallization, X-ray structure determination, and analysis of important drug targets through working with external collaborators. * Management of external structural biology collaborations (CROs) * Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group. Requirements and Qualifications: Education: * PhD degree structural biology or biophysics Required Experience: * 7+ years of drug discovery experience in a pharmaceutical/biotechnology setting; * Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics * Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Knowledge, Skills & Abilities: * Strong knowledge of the drug discovery process, with deep experience in implementing hit identification strategies through candidate selection; * Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience. * Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred. If this excites you, please submit your CV with the title of the position in the subject line to care...@rheosrx.com<mailto:care...@rheosrx.com> This email and any attachments may contain CONFIDENTIAL or PRIVILEGED information and is a private communication between the intended addressee and Rheos Medicines, Inc. If you have received this email in error, distributing, copying, using or disclosing its contents is prohibited. Please notify us of the delivery error by replying to this message and then delete it from your system. Thank you. ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1<https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1> This email and any attachments may contain CONFIDENTIAL or PRIVILEGED information and is a private communication between the intended addressee and Rheos Medicines, Inc. If you have received this email in error, distributing, copying, using or disclosing its contents is prohibited. Please notify us of the delivery error by replying to this message and then delete it from your system. Thank you. ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1<https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1> This email and any attachments may contain CONFIDENTIAL or PRIVILEGED information and is a private communication between the intended addressee and Rheos Medicines, Inc. If you have received this email in error, distributing, copying, using or disclosing its contents is prohibited. Please notify us of the delivery error by replying to this message and then delete it from your system. Thank you. ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1<https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1> This email and any attachments may contain CONFIDENTIAL or PRIVILEGED information and is a private communication between the intended addressee and Rheos Medicines, Inc. If you have received this email in error, distributing, copying, using or disclosing its contents is prohibited. Please notify us of the delivery error by replying to this message and then delete it from your system. Thank you. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
