Join the discussion | Where cryo-EM meets AI
Wednesday, June 8, 2022 | 8 a.m. PDT | 11 a.m. EDT | 5 p.m. CEST
Don’t miss our upcoming Ask the Expert Q session on how structure-based drug
design is being aided by artificial intelligence (AI).
Shuimu Biosciences demonstrates how
One more day to join the Thermo Fisher Scientific web-event on Sep 29.
_Cryo-EM and MicroED in drug discovery_ (incl. routine structure
determination)
Lectures:
* Dr. Christopher Phillips, Astra Zeneca
* Prof. Paul Midgley, University of Cambridge
* Prof. Patrick
You are invited to join a Thermo Fisher Scientific webinar on Sep 29.
_Cryo-EM and MicroED in drug discovery_ (incl. routine structure
determination)
Lectures:
* Dr. Christopher Phillips, Astra Zeneca
* Prof. Paul Midgley, University of Cambridge
* Prof. Patrick
On Sept. 9 and 10 we sponsor 2 lectures at the Microbiology Virtual Week
2020.
"_Using cryo-EM for designing next-gen therapeutics against HIV_" by
Dmitry Lyumkis, [1]PhD [1], Salk Institute
* The basics of single-particle cryo-EM, including the latest
technical advances that are
Last chance to register:
Cryo-EM for Drug Discovery | June 16, 2020
What if you could get structural insights at near-atomic resolution of
your most challenging drug targets at a pace that meets that of your
drug discovery projects?
>From around the world you are invited to join Thermo
Cryo-EM for Drug Discovery | June 16, 2020
What if you could get structural insights at near-atomic resolution of
your most challenging drug targets at a pace that meets that of your
drug discovery projects?
>From around the world you are invited to join Thermo Fisher Scientific
for Cryo-EM
How cryo-EM helps you understand GPCR structure to drive drug design
May 27, 2020 | 9 a.m. PDT | noon EDT | 5 p.m. BST | 6 p.m. CEST
G-protein coupled receptors (GPCRs) are an important family of drug
targets. About one-third of all U.S. Food and Drug
Administration-approved drugs target 108
DETERMINING PROTEIN AND SMALL MOLECULE STRUCTURES WITH MICROCRYSTAL
ELECTRON DIFFRACTION
Thursday, May 30, 2019,
8:00 AM PDT | 11:00 AM EDT | 4:00 PM BST | 5:00 PM CEST
Register here [1]
Microcrystal Electron Diffraction (MicroED) is becoming a critical new
tool for structural analysis of
CRYO-EM IN DRUG DISCOVERY SCIENTIFIC SYMPOSIUM
Apr 23, 2019
MIT Samberg Conference Center
Cambridge, MA 02142
This one-day scientific symposium will highlight the role cryo-EM can
play in the drug discovery process. Leaders in the biopharma industry
will highlight their successes and
THE EMERGING ROLE OF CRYO-ELECTRON MICROSCOPY IN DRUG DISCOVERY
This webcast looks at the emerging role of cryo-EM in drug discovery
and its application to resolve the structure of challenging targets,
such as GPCRs. Experts will share their success in cryo-EM enabled
structure-based drug design
Have you tried Shake-and-Bake? An old program, but works great when you
have mixed real and reciprocal space cake.
Keller, Jacob schreef:
Can anyone index this? It's got mostly split spots and a strange diffuse
scattering background
JPK
***
Jacob
Hi Bernhard,
I just stumbled over this patent, where they add cobalt or nickel ions:
http://www.google.com/patents/WO2013082518A1?cl=en
[0086] Supplementing cell culture media, such as CD FortiCHO and
Freestyle 293, with metal ions does prevent column stripping and improve
histidine tagged
Hmm, what are the perfect bonds, angles for NAD in your protein? remember
that reactive groups can be in a stressed conformation, compared to
ideal in vacuo conformations. As part of their functon.
anyway, you'll have to check the restraints definition file (.cif). Bond
lengths and angles are
That's nothing. Once someone wrote me because the tungsten atom of my
Tungsten containing formate dehydrogenase had dissapeared.
Lost in translation during some autoscripted conversion.
It was corrected soon enough.:)
Cheers,
Hans
Jan Dohnalek schreef:
There have been other manipulations
Dear crystallographers,
Because of the low cost and speed of synthesizing 40- to 60-mer peptides,
I wonder whether anyone has (good or bad) experiences crystalizing such
peptides. In literature, I've found up to 34-mer synthetic coiled coils,
but no other protein class. I can imagine that a
That's progress! A century ago we'd need an infinite amount of monkeys
typing on an infinite amount of typewriters to produce a single paper. Now
we need just a finite amount of gamers to produce 7+ models to get one
that looks quite like a folded protein. And it saved an heavy atom soak as
James,
caseB was lossy compressed.
It is 10% smaller when compressed (gzip, bzip2), so it contains
significantly less information.
cheers,
Hans
James Holton schreef:
Ian Tickle wrote:
I found an old e-mail from James Holton where he suggested lossy
compression for diffraction images (as
Maia,
Usually we live in a macroscopic world and usually gravity is the most
important force. In x-ray diffraction the charge/mass ratio is the most
important paramater (and the density of that).
Hans
Maia Cherney schreef:
Hi all,
Usually density means mass divided by volume. The mass of an
How about disorder and/or partial occupancy? B-factors of the Thr and Cl
seem pretty high compared to the rest of the structure.
Hydrolysis during (possibly weeks/months of) crystallisation is another
option. Check the pH and presence of nucleophiles.
cheers,
Hans
Mike Gretes schreef:
Hello,
19 matches
Mail list logo
