Postdoctoral Position Available Laboratory of Professor Robert M. Stroud, Ph.D. Department of Biochemistry and Biophysics University of California San Francisco, USA
SUMMARY DESCRIPTION: Structural biology of human tight junction membrane proteins The Stroud Laboratory seeks a postdoctoral fellow to pursue the structural characterization of a family of integral membrane proteins critical to tight junction formation and function. These proteins are widely expressed and are implicated in the pathogenesis of many human diseases, including breast and ovarian cancers, inflammatory bowel disease, inherited deafness, hepatitis virus infection, and renal tubule electrolyte transport disorders. As this work is funded by a NIH PSI Biology grant, the successful candidate will work with top-tier biological collaborators. The successful candidate will have the opportunity to: 1. Express biologically relevant integral membrane proteins in a variety of systems (mammalian, insect, yeast, bacterial) 2. Purify target membrane proteins to homogeneity 3. Crystallize and determine the macromolecular structure of these proteins, both alone, and, where applicable, in complex with their ligand(s) START DATE: Immediately REQUIREMENTS: 1. Experience in the expression of eukaryotic proteins using eukaryotic systems 2. Some experience in protein purification and biochemical characterization 3. A desire to learn about membrane protein biochemistry and macromolecular protein crystallography. APPLICATION: Please send (1) your CV, (2) your resume, describing your relevant skills, and (3) a list of three references to: stroud...@gmail.com
