Hi Thomas,Hi all, I have used the amazing software "prime-and-switch" before,it is quite helpful. I have read through your article "Using prime-and-switch phasing to reduce model bias in molecular replacement" , but it is hard for me to understand. So what I am concerned is the basic idea of it. Could you explain the key point with simple words? I found that "prime-and-switch" also uses solvent flattening at the beginning.Is it similar to ordinary solvent flattening? By the way, how to know whether it is effective or not? Which parameter should I concentrate after resolve running, except the electron density? And how to evaulate those parameters?
-- Yolanda