[ccp4bb] occupancy-refinement

Dear CCP4ers, While trying to refine a protein-ligand structure (reso=2.9A) I notice that the density (2Fo-Fc)for the ligand is discontinuous. I also notice that the density for the residues in the ligand binding pocket (LBP) is also very feeble. And when I refine the ligand occupancy the density

[ccp4bb] Ab Biacore

Dear all, Sorry about non crystallographic query. Are there any binding studies (using Biacore) on interactions between antibody and anti-antibody (particularly mouse antibody)? thank you Putcha