design of protein
therapeutics.
http://zymeworks.com/content/careers/PDF/1243-SB_PE.pdf Note: additional
positions are also posted on our website http://zymeworks.com/careers/
Thank you, Paula Lario
Paula Lario Ph.D.
Senior Scientist & Team Lead
Protein Engineering
Zymeworks, Inc
540-1385
Another thing to consider is alternate ligand conformation. The water density
(elongated) and the pocket composition (aromatic) could result in two
alternative binding orientations (of the buffer? I need 3D). I would play
around with models to see if it fits the density.
Paula Lario
#778-828
An advantage with stereo viewing is that you can increase the slab in
a crowed active site and still make sense of it. In my experiance,
valuable for understanding structure function relationships in
flexible proteins.
Paula Lario
On 17-Sep-08, at 8:21 PM, Engin Ozkan <[EMAIL PROTEC
