Ankita,
Fc are different from Fabs. Even if glycosylated their solubility is lower.
Fc stands for constant fragment but also for Fragment crystallizable:
https://en.wikipedia.org/wiki/Fragment_crystallizable_region
From its name, they should be easy to crystallize. If you have problems to
not
Dear CCP4 members,
I am trying to crystallize an antigen-bound to the Fc fragment of an
antibody.
Is Fc fragment difficult to crystallize compared to Fab? Are there any
commercial screens widely known to crystallize Fc fragment or antibodies?
I would appreciate if you can share any experience
