Dear all, We are currently seeking a crystallographer to join the Biomolecular Structure group at our research facility (Granta Park, Cambridge, UK), to work on GPCR structure determination to enable drug discovery efforts.
The successful candidate is expected to work in the following areas: - Express and purify GPCRs for structural and biophysical methods. - Set up and optimise vapour diffusion and LCP crystallisation experiments. - Collect x-ray diffraction data at synchrotron sources. - Solve and refine structures. - Present results (written and oral) to internal and external audiences. The preferred candidate will have the following : - Related experience (a PhD level qualification would be advantageous but is not an essential prerequisite) in protein crystallography or related discipline and be familiar with purification of proteins from recombinant expression systems such as *E. coli* or baculovirus/insect cells, setting up crystallisation experiments including Lipidic Cubic Phase crystallisation, X-ray data collection, data processing, structure solution and refinement of novel structures and follow-on complexes. - Experience of working with GPCRs or other membrane proteins would be advantageous. - Experience of working in a drug discovery environment where structural studies are used to drive compound design and medicinal chemistry would also be beneficial. The successful candidate will join the Crystallography team headed by Dr. Andrew Doré, and will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2021_1BMS. The closing date for applications is 25th March 2021. Strictly No Agencies Please do not reply directly to this email and apply through our career portal : https://cezanneondemand.intervieweb.it/heptares/jobs/crystallographer__1_year_fixedterm_maternity_cover_12729/en/ Kind regards, Prakash RUCKTOOA ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
