Hi Jason,
RosettaDesign server will do just that:
http://rosettadesign.med.unc.edu/
You can specify that certain residues remain unchanged (say active site),
that they fall into defined physico-chemical categories (polar, hyrophobic,
etc), or let the server change all residues into whatever i
Hi Jason,
While it's not quite what you described, I'd recommend you check out the
Secondary Structure Matching server at the EBI:
http://www.ebi.ac.uk/msd-srv/ssm/ssmstart.html
That will (hopefully!) give you previously deposited structures which share a
similar fold to your query pdb file.
I am looking for software or a server to run the 3D-1D profile search
in reverse: that is I have a new structure (not in yet deposited in
PDB) and I want to see what sequences might fit well to this 3D
structure.
Can someone point me in the right direction?
-jason
