Senior/Research Scientist (Membrane Protein Biochemist), Protein Structure & Biophysics Group, Slough, UK
Make your mark for patients. We're here because we want to build the future and transform patients' lives for the better. At UCB, our people are our experiences and achievements, our passion and drive. That's why we're looking for talented individuals with diverse backgrounds and experiences - not just the best and brightest, but those who care about making a meaningful difference in the lives of patients. We promote an environment of diversity, openness, and respect where people can make valuable contributions. An exciting journey lies ahead. Will you join us in pushing the boundaries of what's possible? UCB has an excellent track record in utilising structural information in the development of both small molecule and antibody therapeutics. To support this capability, we have an exciting opportunity for a membrane protein biochemist to join the Protein Structure & Biophysics (PS&B) department and contribute to UCB's goal of bringing real benefits to patients. We are looking for an innovative, enthusiastic protein biochemist with expertise in the expression and purification of integral membrane proteins for use in structural studies to join our Protein Expression & Purification team, based in Slough, UK. The role offers the opportunity to work alongside a dynamic and diverse group of scientists that make up the PS&B department and to interact with the wider research organisation on our drug discovery programs. Responsibilities * Take a lead role in the expression and purification of multi-pass membrane proteins for structural studies. * Collaborate with other members of the PS&B department and across multiple disciplines (project teams, medicinal chemistry, antibody discovery and the CADD group) to collectively bring value to our therapeutic projects. * Interpret and communicate experimental data at cross-functional meetings, highlighting technical challenges and providing potential solutions. * Keep abreast of and implement technology developments within the area of protein expression and purification with a key focus on multi-pass membrane proteins. Profile Candidates will have a PhD (or graduate with 4-5 years' experience) with significant hands-on experience in recombinant protein production. Preference will be given to candidates who have spent time working within labs recognised for their expertise in the field of multi-pass membrane proteins. We are looking for candidates who can demonstrate the following skill sets: * Ability to interrogate protein structures to optimize expression construct design. * Familiar with a range of expression systems including: E.coli, insect cell and mammalian cell. * Fully independent in protein purification techniques and extensive working knowledge of AKTA purification platforms and associated software. * Knowledge of and ideally hands-on experience in producing membrane proteins in nano-discs, liposomes and SMALPS. * An expert in the techniques required in the expression and purification of multi-pass membrane proteins for use in structural studies. * Not essential, but good to have experience of performing structure determination and/or mass spec analysis of membrane proteins. * An excellent knowledge of the literature around the generation of multi-pass membrane proteins for structural studies. In addition, all applicants must possess excellent written and verbal communication skills. To apply please send your CV and cover letter to protein.purificat...@ucb.com<mailto:protein.purificat...@ucb.com> Only candidates able to work in the UK will be considered for this role. ________________________________ Legal Notice: This electronic mail and its attachments are intended solely for the person(s) to whom they are addressed and contain information which is confidential or otherwise protected from disclosure, except for the purpose for which they are intended. Dissemination, distribution, or reproduction by anyone other than the intended recipients is prohibited and may be illegal. If you are not an intended recipient, please immediately inform the sender and return the electronic mail and its attachments and destroy any copies which may be in your possession. UCB screens electronic mails for viruses but does not warrant that this electronic mail is free of any viruses. UCB accepts no liability for any damage caused by any virus transmitted by this electronic mail. (Ref: #*UG1107) [Ref-UG1107] ________________________________ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
