Project Title: Membrane Protein Nanocrystallography
Post Doc Location: AstraZeneca Mölndal, Sweden Description of Opportunity: We have an exciting opportunity for a Ph.D. scientist to join the Discovery Sciences department, a global organisation supporting all innovative Medicines Units (iMeds) within AstraZeneca. The project Membrane Protein Nanocrystallography (NanoMem) is part of the Marie Curie Initial Training Network funded by the European Commission and is a close collaboration between ten different laboratories in Europe from both Universities and Industries. The aim is to exploit synchrotron based micro-focus X-ray beams to address challenging diffraction studies from small membrane protein crystals and the revolutionary new possibilities created by the Xray Free Electron lasers which combine ultrafast X-ray pulses with high brilliance focussing capabilities. NanoMem will exploit the new scientific opportunities created by these technical capabilities through close collaboration between structural biologists, beamline engineers, software developers and industrial partners like AstraZeneca and others. NanoMem is an interdisciplinary training network incorporating membrane protein crystallisation, microcrystal and nanocrystal preparation and handling technologies, microfocus diffraction, software development, structure based drug design and serial femtosecond crystallography. The postdoc is expected to contribute to the overall objectives of the Marie Curie Initial Training Network NanoMem through networking, secondments and joint experiments with the other partners involved. The role's major responsibilities Develop and explore approaches to prepare small well diffracting membrane protein crystals Show strong initiative in developing ideas and bringing them forward to functional use within AstraZeneca and within the NanoMem network Communicate results both within AstraZeneca, the NanoMem Collaboration and externally at meetings and through publications Develop skills in and understanding of the drug discovery process Work collaboratively with other experts within Discovery Sciences, the iMED organisation and within the NanoMem network Minimum experience A recent PhD in one or more of the following areas: Biochemistry focussing on membrane proteins Structural Biology with an interest in membrane protein Preferred experience/requirements Experience working with membrane protein expression and purification Experience in crystallization/X-ray crystallography Ability to design and carry out research independently Strong written and oral communication skills Motivation to work in a multidisciplinary and international environment is fundamental to this position For this position the eligible researcher must not have lived in Sweden more than 12 months for the last three years More Information / Main Supervisors: AZ: Margareta Ek, Ph.D. Associate Principal Scientist, Structure & Biophysics, Discovery Sciences. margareta.e...@astrazeneca.com Arjan Snijder,Ph. D. Associate Principal Scientist, Reagents and Assay Development, Discovery Sciences. arjan.snij...@astrazeneca.com Apply online no later than November 14, 2012. To find the ad, search for job number: "MOL000000VP" at http://www.astrazeneca.se/karriar/ledig-tjnstervacancies/job-search--en Please refer to the job number and the title in all correspondence. _____________________________________________________________________________________________ Patrik Johansson Associate Principal Scientist AstraZeneca, R&D | Discovery Sciences Pepparedsleden 1, 43183 Mölndal, SWEDEN P +46 31 70 64570, F +46 31 77 63792 -------------------------------------------------------------------------- Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.
