The Institute of Cancer Research Section of Structural Biology Chester Beatty Laboratories Chelsea, London
Postdoctoral Training Fellow Structure-Based Development of Tankyrase Inhibitors The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organisation. In the 2008 Higher Education Funding Councils' Research Assessment Exercise, The ICR received the highest percentage of research assessed as four stars, world leading, in the areas of biological sciences and cancer studies. We came top of the Times Higher Education overall table of HEIs that submitted to more than one UoA - ranking it as the UK's leading academic research centre, with 37% of activity ranked 4* (world leading) and 42% ranked 3* (internationally excellent). The Section of Structural Biology at ICR is exceptionally well equipped for all aspects of modern structural biology, with state-of-the-art laboratories for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, X-ray crystallography and electron microscopy. Excellent synchrotron access (~ 2 days/month) is available through rolling beam allocation programmes at Diamond and ESRF. Applicants must have a PhD, and experience in recombinant expression, protein purification, crystallisation and X-ray crystallography. Information on our previous work in this field can be found by searching PubMed and via the ICR Website http://www.icr.ac.uk/index.shtml A Postdoctoral position funded by the Wellcome Trust Strategic Drug Development Initiative is available immediately in the laboratory of Professor Laurence Pearl FRS, to analyse complexes of novel small-molecules with the transcriptional regulatory enzyme, tankyrase. The postholder will be responsible for expression and purification of the target protein constructs, and for co-crystallization and structural analysis of complexes of tankyrase with novel inhibitors, emerging from the work of the collaborating laboratories. Applicants should hold a PhD in a biological or chemical science, have experience of macromolecular crystallography and recombinant protein expression with evidence of a good publication record. Experience in structure-based drug development and of working in a multidisciplinary project team, would be an advantage. The starting salary for the position will be in the range £26,996 to £33,188 p.a. inclusive (based on previous post-doctoral experience). Informal enquiries can be made to Professor Laurence Pearl (laurence.pe...@icr.ac.uk). Please note – this address is for enquiries ONLY and CVs must be submitted in line with the instructions below. For further particulars and details of how to apply, please visit our website at www.icr.ac.uk Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C341. Closing date: Monday 10th May 2010 -------------------------------------------------------------------------------- Laurence H. Pearl PhD FMedSci FRS Professor of Protein Crystallography and Section Chairman Section of Structural Biology, Institute of Cancer Research Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK Phone +44-(0)20 7153 5422 : Secretary +44-(0)20 7153 5443 : FAX +44-(0)20 7153 5457 -------------------------------------------------------------------------------- "Live Simply and do Serious Things .. " - Dorothy Crowfoot Hodgkin -------------------------------------------------------------------------------- The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
