------------------------------------------------------------------------------------------------------- Postdoctoral position in membrane protein structural biology and pharmacology -------------------------------------------------------------------------------------------------------
The laboratory of Hiro Furukawa at Cold Spring Harbor Laboratory (CSHL) is seeking an enthusiastic postdoc with dynamic interests in solving problems in neurological diseases and cancer using biochemical and biophysical techniques. We conduct x-ray crystallography on transmembrane proteins to understand basic mechanisms of ion and substrate transport and on fragments of water soluble domains to answer specific pharmacological questions. We use diverse techniques to address protein functions including electrophysiology, imaging, calorimetry, and phage-display. We also attempt to understand critical protein-protein interactions in signal transduction cascades in neurons and cancer cells using a combination of proteomics, electron microscopy, and x-ray crystallography. Other projects involve structure-based protein engineering of therapeutic antibodies. We have a state-of-the-art equipment to conduct membrane protein biochemistry and crystallography such as Mosquito LCP, frequent access to synchrotron light sources including NSLS and APS, and excellent facility for phage-display, proteomics, and microscopy. CSHL offers a unique scientific environment to interact with scientists within the institute as well as from outside at the prestigious CSHL courses and meetings (including the famous 2-week course, “X-ray Methods in Structural Biology”). Highly interactive and educative nature of CSHL has traditionally created many successful independent scientists with unique and innovative visions. A qualified candidate should hold or soon expected to hold (within ~1yr) Ph.D. in the area of crystallography, electron microscopy, and biochemistry and have experiences in basic molecular biology, biochemistry, and protein expression. Experience in x-ray crystallography or electron microscopy is desired but not necessary. Please see the lab website (http://www.cshl.edu/public/SCIENCE/furukawa.html - will be updated soon) for further information and send CV with a brief research statement as well as 2-3 contacts for references to furuk...@cshl.edu. Thanks.
