Dear all, For anyone interested in giving fragment screening a try, Zenobia has been offering a 352 compound fragment library designed to serve as a first-pass screen by x-ray crystallography (and other methods such as SPR, NMR) since March. The library was prepared and reviewed by experienced FBLD scientists from SGX Pharmaceuticals and Abbott Laboratories.
The first batch of the library, prepared at 200mM in 100% DMSO, has sold-out. For our second batch, to provide additional flexibility in the choice of co-solvent, we have changed the format to dry film. This allows testing in systems sensitive to DMSO as a co-solvent. As before, the library is plated to facilitate screening of shape-diverse mixtures and comes with simple screening instructions/suggestions. We offer this to help facilitate new and existing laboratories give fragment screening a try - and welcome your feedback on libraries that may be helpful to you! If you would like additional information or have comments please contact Leslie Hernandez: les...@zenobiatherapeutics.com<mailto:les...@zenobiatherapeutics.com>. Thanks, Vicki Nienaber
