Re: [ccp4bb] Why Does Detwinning Not Work?

> I do not know what the current state is of developing the ML target for > refining > against twinned (I, F) data is. > Formulas are there, see "Maximum likelihood refinement for twinned structures" here: https://www.phenix-online.org/newsletter/CCN_2011_01.pdf someone just need to code it.

Re: [ccp4bb] Why Does Detwinning Not Work?

of observations, right? JPK From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Bernhard Rupp Sent: Tuesday, October 11, 2016 8:09 AM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] Why Does Detwinning Not Work? Tom Terwilliger recently pointed me to a relevant discussion on the phenix

[ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work?

: [ccp4bb] Why Does Detwinning Not Work? I seem to recall that Gerard was also looking at incorporating proper ML refinement for twinned data into the Global Phasing software, but I’m not sure on the status. Best, Steve From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf

Re: [ccp4bb] Why Does Detwinning Not Work?

, 2016 8:09 AM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] Why Does Detwinning Not Work? Tom Terwilliger recently pointed me to a relevant discussion on the phenix bb: http://phenix-online.org/pipermail/phenixbb/2013-May/019836.html​ In essence, in case of detwinning, the refinement target

Re: [ccp4bb] Why Does Detwinning Not Work?

: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of herman.schreu...@sanofi.com Sent: Tuesday, October 11, 2016 1:23 PM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] AW: [ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work? Normally, twinned refinement is the way to go. However, if the maps

[ccp4bb] AW: [ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work?

Auftrag von Eleanor Dodson Gesendet: Dienstag, 11. Oktober 2016 13:09 An: CCP4BB@JISCMAIL.AC.UK Betreff: Re: [ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work? Search for: "experimental phasing with detwinned data" and you will find some hits. You need a low degree of twinning, and a

Re: [ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work?

Auftrag von > *Chris Fage > *Gesendet:* Dienstag, 11. Oktober 2016 10:40 > *An:* CCP4BB@JISCMAIL.AC.UK > *Betreff:* Re: [ccp4bb] Why Does Detwinning Not Work? > > > > Dear Jacob, > > > > I'm not an expert on the topic, but from my experiences with twinning I &g

Re: [ccp4bb] Why Does Detwinning Not Work?

t detwinning I think there would have been no crystal structure in the end... Cheers, Fred. From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Keller, Jacob Sent: Tuesday, October 11, 2016 2:15 AM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] Why Does Detwinning Not Work? Dear Cryst

[ccp4bb] AW: [ccp4bb] Why Does Detwinning Not Work?

Auftrag von Chris Fage Gesendet: Dienstag, 11. Oktober 2016 10:40 An: CCP4BB@JISCMAIL.AC.UK Betreff: Re: [ccp4bb] Why Does Detwinning Not Work? Dear Jacob, I'm not an expert on the topic, but from my experiences with twinning I can agree with you. I recently solved my second twinned structure by MR

Re: [ccp4bb] Why Does Detwinning Not Work?

Sorry--I think you were referring to phasing, not refinement. I hope my message is still relevant. Cheers, Chris On Tue, Oct 11, 2016 at 10:39 AM, Chris Fage wrote: > Dear Jacob, > > I'm not an expert on the topic, but from my experiences with twinning I > can agree with you.

Re: [ccp4bb] Why Does Detwinning Not Work?

Dear Jacob, I'm not an expert on the topic, but from my experiences with twinning I can agree with you. I recently solved my second twinned structure by MR (twin fraction of 0.43, as estimated by Xtriage). Performing twin refinement in Refmac or phenix.refine dropped the R-factors, as expected,

[ccp4bb] Why Does Detwinning Not Work?

Dear Crystallographers, Based on some data sets I have looked at and anecdotal-type evidence here and there I have gotten the impression that detwinning does not help in structure solution. (Please let me know if you have a case where detwinning saved the day.) Is there a clear answer to this