Dear community,

sorry, for the slight off-topic question.

I am studying the complex of two human proteins. Till now, all co-crystallization trials (some dozen plates) were negative, but cross-linking and MST studies suggested a stable, mid-affinity complex. Therefore, I wanted to dock the proteins using these experimental information to get ideas for some more rational construct designs, e.g. fusion constructs.

After unsuccessfully trying Hex docking and Rosetta, I heard of the very old 3D-dock program which is unfortunately not maintained anymore. The package consists of FTDock, RPScore and MultiDock. We downloaded and installed it from the webpage (http://www.sbg.bio.ic.ac.uk/docking/download.html), but RPScore and MultiDock are not available. Also Google searches were negative ...

My questions are:
Does anybody may have a backup of RPScore (and MultiDock) somewhere and could drop me a copy? Do you have any suggestions of protein docking programs which might be able to be constrained by my experimental results, especially the cross-linking results?

Thanks a lot in advance!

Best regards,
Julian Pfahler

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