Dear community,
sorry, for the slight off-topic question.
I am studying the complex of two human proteins. Till now, all
co-crystallization trials (some dozen plates) were negative, but
cross-linking and MST studies suggested a stable, mid-affinity complex.
Therefore, I wanted to dock the proteins using these experimental
information to get ideas for some more rational construct designs, e.g.
fusion constructs.
After unsuccessfully trying Hex docking and Rosetta, I heard of the very
old 3D-dock program which is unfortunately not maintained anymore. The
package consists of FTDock, RPScore and MultiDock. We downloaded and
installed it from the webpage
(http://www.sbg.bio.ic.ac.uk/docking/download.html), but RPScore and
MultiDock are not available. Also Google searches were negative ...
My questions are:
Does anybody may have a backup of RPScore (and MultiDock) somewhere and
could drop me a copy?
Do you have any suggestions of protein docking programs which might be
able to be constrained by my experimental results, especially the
cross-linking results?
Thanks a lot in advance!
Best regards,
Julian Pfahler