[CMLHope] Re: loss of effectiveness of gleevec and sprycel

2012-03-13 Thread skink1100
Well the good thing about switching to sprycel was all my side effects disapeared...muscle cramps, and diarhea mostly...definitely a mild impact drug when it works. I am going to get tested for mutations...that could be the issue... On Mar 12, 2:40 pm, lrc lrc wrote: > Don't worry.  Same thing h

[CMLHope] Re: loss of effectiveness of gleevec and sprycel

2012-03-13 Thread skink1100
ratio have increased over past 6month from .01 on 9/26 to .151 on 1/5 to 1.042 on 3/5...log reduction reported as 2.599 on 9/26, 1.436 on 1/5 to .598 on 3/5does not look good to me. On Mar 13, 7:56 am, Frank wrote: > What were your last 12 months bcr/abl test results? Regards, Frank > > On Ma

Re: [CMLHope] Re: loss of effectiveness of gleevec and sprycel

2012-03-13 Thread margood18
Today is my third anniversary of diagnosis and starting Gleevec. About one year into it, I had my bone marrow work come back showing a possible mutation (there was none) and elevated BCR-ABL AND FISH. I was bumped from 400 mg to 600 mg and that brought me back in line. In this last year my

Re: [CMLHope] loss of effectiveness of gleevec and sprycel

2012-03-13 Thread skink1100
I was on 600mg per day of gleevec...than 100mg of sprycel...now 140mg sprycel On Monday, March 12, 2012 10:22:49 PM UTC-4, robert goodrich wrote: > > just out of curiosity what dosage are you on.my wife is going on 11 > years with gleevec,but has always been on a low dosage.200 mg a > d

Re: [CMLHope] Re: loss of effectiveness of gleevec and sprycel

2012-03-13 Thread Donald Donofrio
May 1 will start my wife's 13th year with CML and gleevec.  Her readings are normal and she returns to the doctor every 5 weeks.  her problem is she has spinal sinuous and has to us a walker.  The CML is in remission.   Don Donofrio From: Frank To: CMLHope

Re: [CMLHope] Side effects

2012-03-13 Thread Myvety2k
I'll give it a try, thanks for the information. greenie In a message dated 3/12/2012 11:33:05 P.M. Eastern Daylight Time, esd...@rogers.com writes: I don't know if it is a myth or not, but I was told many years ago to make sure I had a breakfast heavy in PROTEIN before taking my Gl

Re: [CMLHope] loss of effectiveness of gleevec and sprycel

2012-03-13 Thread Myvety2k
I read your post and I have been on 300 mg. for the last 12 years. greenie In a message dated 3/12/2012 10:22:57 P.M. Eastern Daylight Time, cinem...@yahoo.com writes: just out of curiosity what dosage are you on.my wife is going on 11 years with gleevec,but has always been on a l

[CMLHope] Re: loss of effectiveness of gleevec and sprycel

2012-03-13 Thread Frank
What were your last 12 months bcr/abl test results? Regards, Frank On Mar 12, 1:54 pm, skink1100 wrote: > I have had cml for nearly 10 years.  For several years I was at the > not detectable level in my pcr tests.  Last year the gleevec seemed to > no longer be as effective...and my doctor switch

Re: [CMLHope] loss of effectiveness of gleevec and sprycel

2012-03-13 Thread Donald Donofrio
My wife has been on Gleevec since we went to Detroit in phase three of testing. She takes 200 mg. daily.  My name is Don    Don Donofrio From: robert goodrich To: "cmlhope@googlegroups.com" Sent: Mon, March 12, 2012 10:22:49 PM Subject: Re: [CMLHope] loss of