Dear Daniel,
That was a typo, we all have 23 pairs of normal chromosomes so
46(X,Y) [20] hopefully soon if your report does not read so
already ;-) Believe me, my husband is trying to get out of his 2 year
BMA and I have full sympathy with all CML patients. We have junior
docs practicing the
anjana thanks for your very lucid description of the different flavors
of cytogenetics analysis (and just to be clear both karyotyping and g-
banding are both cytogentics analyses). also, let's hope that my bmb
results don't indicate i have 'all 36 chromosomes'--that would be very
bad news indeed.
I think Daniel is reflecting what most of us see happening. Namely,
the 12 month BMB for patients who are responding well seems to be
disappearing, even though some continue to cling to the more
conservative approach of doing a BMB every 12 months. Dr Druker's
patients report that he stretches B
Dear Daniel,
When you have a bone marrow aspiration (BMA) or a bone marrow biopsy
(BMB), the lab will take the aspirated marrow and culture 20 metaphase
(dividing) cells. Then by a technique called G Banding, the lab tech
can look into the microscope and see all 36 chromosomes in each of
your
thanks for your thought anjana. you raise a topic that is receiving a
lot of attention in recent cml research--the presence of chromosomal
abnormalities (CA) in PH- cells. i think the 3 abstracts you posted
are pretty representative of the literature in that the two
statistical analyses indicated
Dear Daniel,
It is recommended to do a BMB every 6 months until CCR by the CML
experts and yearly after that. While you are right that the BCR-ABL
mutations give rise to Gleevec resistance, the reason doctors still
insist on BMBs for karyotyping is that in rare cases, additional
chromosomal ab
thanks timothy,
just to clarify, both chromosomal abnormalities and point mutations
are mutations--the difference is a matter of scale. point mutations
are small-scale events involving only a few SNPs while 'chromosomal
abnormalities' (e.g., translocations, isochromosomes, trisomy, etc...)
are lar
Daniel;
Welcome to our group..
I just wanted to let you know that all doctors are not "BMB"
happy.I've seen five different hema/onc. since my diagnosis
back in January 2004.& my latest says that she only does one if
she sees something in the peripheral blood that indicates c
Daniel
There are point mutations and there can be chromosome abnormalities.
First the mutations. A point mutation in the BCR-ABL gene changes the
protein folding such that its harder (varying degrees) for one of the
drugs to bind to the BCR-ABL protein to turn it "off". Its difficult
to put a
trey and timothy,
thanks for your thoughts. i spoke to my onc today and asked him
similar questions and it seems the consensus is that the primary
advantage of the bmb is that karyotyping can detect gross mutations.
i'm going to go ahead and have it done for my upcoming 6 month appt,
but am still
Daniel,
Just to add a couple items. BMB certainly looks for things that PCR
and FISH cannot see, as outlined above. The best uses of a BMB are at
diagnosis (where it is very necessary) and after that for early
detection of additional chromosomal mutations that might infer
potential disease progr
Daniel, you have studied well.
You raise a very valid point. I think the number of bone marrow
biopsies is being discussed among the experts and will decrease in the
near future.
Couple points.
Karyotyping Cytogenetics looks at cells in metaphases. Most will
probably be myeloid in nature but
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