Thanks for all the information that has been shared on this topic.
Received and email from Dr Cortes this evening and he recommends a
full evaluation to determine if this is relapse or not. Will talk to
my local dr in the am to see if we will do this here or in Houston. I
wanted to let you all k
Dear Lenda,
I am so glad you have reached PCR 3-log on Sprycel. I just posted
the results of the Sprycel versus 800mg Gleevec trial for patients
resistant to lower Gleevec doses and indeed, Sprycel does better than
800mg Gleevec from the trial. But hearing experiences are even
better! I hope
Yes, quite right, Tim. We need to look at the newly diagnosed patient
Sprycel versus Gleevec randomized trial data to be very accurate :-)
However, in last ASH 2007, the Gleevec-resistant patient randomized
trial data Sprycel versus 800mg Gleevec was reported and more MMRs
were seen with Sprycel
Dear Jeanie,
FISH from the blood is seen most of the time to have lower values
than FISH from the marrow. There are studies on that. Marrow FISH is
more reliable than peripheral blood FISH.
My husband has 4 vials of blood taken for quantitative PCR. The
more the volume of the blood, the g
This also happened to me this past October. I was on 400mg of Gleevec
from June
'05 to October '06 when my bcr-abl spiked. The doctor waited for four
weeks and
ran the test again to be sure, but it spiked even further in
November. Instead
of increasing my dose to 600 or 800 he switched me to Sp
This also happened to me this past October. I was on 400mg of Gleevec from
June
'05 to October '06 when my bcr-abl spiked. The doctor waited for four weeks
and
ran the test again to be sure, but it spiked even further in November. Instead
of increasing my dose to 600 or 800 he switched me
Just wanted to add to Anjana's note that the study she referred to
compared current Spyrcel treatment to historical data with 800 mg
Gleevec. MD Anderson is also running a trial in newly diagnosed CML
patients treated with Tasigna and it is also showing that while
Cytogenetic responses are much
Hi all,
Just wanted to add that a FISH test was done on my marrow when I had the BMA
done.
The one on my marrow was positive and the one on my blood was negative.
I just don't understand why?
I though my onc orderd a PCR drip test this tinme.
Does anyone know what this is?
They took 4 vials of
Hi Kathy,
I am now on 600 mgs and doing pretty good on it.
I will get a cbc tomorrow and let you know the results.
I wrote to Dr Druker and he thought I might have a mutation; I hope not but
we do have the other meds to turn to if we get it.
I should get the PCR results next week.
I pray yours
Dear Kathy,
You ask a very pertinent question. We can only go by the data from
the newly diagnosed patient Sprycel versus 800mg Gleevec trial, the
data was presented at ASCO 2007 by Dr. Atallah of MDACC. I am giving
the article below from Oncology News. The MMR rate (major molecular
response
Thank you for posting. I think your suggestions are perfect, and this
is what I will ask my doctor for on Monday. I know these second
generation drugs are quite new, but the only info I have found talks
about the rates of CHR and cytogenetic response. Do you know if there
is hope that they can
Thanks Jeanie,
I was hoping to hear from you after I read your November posts about
your own FISH tests. On December 27th my white count was up slightly
to about 13K. While all my counts had returned to normal in January,
my doctor ordered the FISH. My plan is to ask for a BMB for a
cytogeneti
Hi Kathy,
My recent FISH done from BMA came back with positive philies cells.
However, there were no blast cells. The reason my onc did a BMA was that my
platelets were increasing. He increased my Gleevec to 600 megs and I
recently had a PCR test; don't have the results yet. How are your bl
A 4% positive FISH could possibly be a false positive, since it has
approx 5% margin of error. But you should not assume that is the
case, but should have a PCR done, and a BMB is also a good idea if you
have not had one recently. You might also want to have a Gleevec
Resistance Test, since that
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