-Caveat Lector-

----- Original Message -----
From: <[EMAIL PROTECTED]>
To: <[EMAIL PROTECTED]>
Sent: Saturday, November 18, 2000 8:28 PM
Subject: [firebase-news] Bone problems in Gulf WAr Veterans


>
> Chemicals Implicated in Reduced Bone Formation in Gulf War Veterans
>
>
> By Pam Harrison
>
> TORONTO (Reuters Health) - Impaired bone formation has been identified
> in Gulf
> War veterans with symptoms of ill health, including musculoskeletal
> symptoms
> ascribed to the Gulf War syndrome, British researchers report. The
> findings were
> presented here during the 22nd annual meeting of the American Society
> for Bone
> and Mineral Research.
>
> Dr. Juliet Compston, of the University of Cambridge School of Clinical
> Medicine,
> and colleagues assessed eight undecalcified sections of bone taken on
> iliac crest
> bone biopsy from 17 British Gulf War veterans, mean age 35 years, who
> were
> involved in litigation related to symptoms ascribed to the Gulf War
> syndrome.
> Thirteen healthy, age-matched men served as controls.
>
> "Basically what we found is that the cells which make bone are forming
> less well
> than normal and the rate at which bone is turning over is also very low
> [among
> veterans compared with controls]," Dr. Compston told Reuters Health in
> an
> interview. These changes may or may not predispose veterans to
> osteoporosis over
> the next few decades, she observed.
>
> Interestingly, though, 14 of the 17 Gulf War veterans assessed reported
> a history of
> fracture, Dr. Compston said. While some of these fractures were
> definitely
> traumatic, "some seemed to be related to fragility, even though it's
> hard to be
> absolutely certain about this from history alone," she added.
>
> Dr. Compston cautioned that the reduced bone formation observed in these
> veterans may have more to do with changes in lifestyle than exposure to
> multiple
> chemicals during the Gulf War. Veterans involved in the British study,
> for example,
> were not working, some of them drank quite heavily and some smoked, and
> they
> engaged in little physical activity.
>
> "All of these factors in themselves could lead to abnormalities in
> bone," Dr.
> Compston noted, "so we cannot say from this work that the abnormalities
> we
> defined are directly related to the multiple chemical insults we know
> soldiers had in
> the Gulf War."
>
> Nevertheless, she said, it is theoretically possible that the chemical
> exposure that
> veterans experienced during the Gulf War could interfere with cellular
> mechanisms
> that produce normal bone formation. Organophosphates, among other
> chemicals
> that veterans were exposed to during the war, can break down
> acetylcholine
> esterase and thus impair bone cell formation.
>
> Dr. Compston also noted that, as other investigators have reported,
> farmers
> exposed to organophosphates in sheep dip have similar histomorphometic
> changes
> associated with reduced bone formation.
>
> >
> FIREBASE HQ http://www.firebase.net
>

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