-Caveat Lector-

 CJD, POSSIBLE ASSOCIATION WITH BSE
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 [1]
 Date: Thu 5 Dec 2002
 From: Werner Slenczka <[EMAIL PROTECTED]>

"CJD, possible association with BSE"
 ---------------------------------------------------------------------
 I want to make a brief comment on the report from the Guardian saying that
 mice expressing the human PrP-gene may develop the picture of classical
 Creutzfeldt-Jakob disease (CJD) or the picture of bovine spongiform
 encephalopathy (BSE).

 The possibility of pathogen transmission from bovines to humans has
existed
 for many years before the appearance of BSE. It must be realized that the
 production of smallpox vaccine and its use in humans was accompanied by
 introduction of crude bovine proteins into the human skin. This type of
 vaccine was administered for more than 100 years to most children on the
 northern hemisphere. The vaccine was produced in calves, but passages in
 sheep or in rabbits were also made to prevent the accumulation of some
 pathogens. The smallpox vaccination might have been a cause of sporadic
 cases of CJD in humans as long as it was routinely applied.

 --
 Dr Werner Slenczka
 Inst. of Virology
 Robert Koch-Str. 17
 35037 Marburg
 <[EMAIL PROTECTED]>

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