-Caveat Lector- Dave Hartley http://www.Asheville-Computer.com http://www.ioa.com/~davehart -----Original Message----- From: MichaelP [mailto:[EMAIL PROTECTED]] Sent: Friday, October 15, 1999 9:36 AM To: unlikely.suspects :; Subject: NY TIMES on GM Report publication NY TIMES October 15, 1999 A Disputed Study Suggests Possible Harm From Genetically Altered Food By ANDREW POLLACK A prestigious medical journal is publishing a study suggesting that genetically modified food may be harmful, even though the research has been widely criticized by scientists and was found wanting by some of the journal's own referees. The Lancet, a journal based in England, said had it decided to publish the study in part to spur debate and to avoid being accused of suppressing information on a controversial subject. The data "are preliminary and nongeneralisable, but at least they are now out in the open for debate," Richard Horton, the journal's editor, wrote in an editorial accompanying the study, which will appear on Saturday. Publication of the paper in a peer-reviewed journal is likely to further fan fears about genetically engineered crops in Europe, where consumers and supermarkets are widely rejecting what opponents have dubbed Frankenfoods. The study is also likely to be seized upon by opponents of such food in the United States, where consumers have until recently expressed little concern about the genetically altered corn and soybeans that have swept quietly into their diets. "I think it gives it a certain scientific credibility," said Charles Margulis of the Washington office of Greenpeace. "It's going to increase concern here in the United States." But the decision to publish the study is itself generating debate: some scientists say the Lancet has lowered its standards and subverted the peer review process. "This would never have been published in a plant biology journal," said Maarten J. Chrispeels, professor of biology at the University of California at San Diego and editor of the journal Plant Physiology. He said the experiment was too poorly designed to support the paper's conclusions. In an interview from London, Horton said, "In answer to the question, 'Have you lowered your scientific standard?', the answer is no." Three of the five scientific experts who reviewed the paper supported its publication on technical merit, he said, albeit after numerous revisions. One reviewer opposed publication and the fifth thought the study was flawed but should be published nonetheless in the public interest. The paper reports that rats fed genetically modified potatoes experienced a thickening of their stomach walls and other changes in their intestines. The medical significance of this was not stated, but such a thickening suggests a reaction to some toxin or irritant. The potatoes contained an implanted gene from the snowdrop plant that caused the potatoes to produce a lectin, a type of chemical found in nearly all plants that helps them fend off insects. Rats in the control groups were fed either ordinary potatoes or potatoes spiked with lectin. Some of the changes in the stomachs of the rats fed either the genetically altered potatoes or the ones spiked with lectin seemed to come from the presence of the chemical, which some scientists said was not particularly surprising, because many lectins are toxic. But other changes, specifically a thickening in the jejunum section of the small intestine, occurred only in rats fed the genetically altered potatoes, not the lectin-spiked or nonmodified potatoes. That, the authors said, suggested that the changes could have been caused by the genetic engineering itself, an assertion that raises much broader concerns about so-called biotech foods. The study was part of broader research done by Arpad Pusztai, a scientist formerly at the Rowett Research Institute in Scotland. Last year, Pusztai ignited a furor in Europe when he said on a television show that rats fed the transgenic potatoes had experienced stunted organ growth and immune system problems. The Rowett Institute did not renew Pusztai's employment contract and concluded in a review that his data did not support his conclusions. The Royal Society, Britain's senior scientific academy, reviewed Pusztai's work and earlier this year declared it too flawed to draw any conclusions about the effects of the transgenic potatoes, in part because because the experiments had lacked proper controls. The Royal Society yesterday issued a statement reiterating that conclusion and criticizing The Lancet for lending "some authenticity" to the study. In his commentary, Horton said publication was not meant to be a "vindication" of Pusztai and his co-author of the paper, Stanley W. B. Ewen, a pathologist at the University of Aberdeen in Scotland. The Lancet also published a sharp critique of the paper by scientists at the National Institute for Quality Control of Agricultural Products, which is based in the Netherlands. The critique criticized the study for not, for example, accounting for big differences between the genetically modified and ordinary potatoes that were not associated with genetic engineering. They also said the study did not find consistent effects. Pusztai could not be located and did not respond to an E-mail request seeking comment. Ewen declined to be interviewed, but said in a statement: "We are convinced that further experimental work is required to test the safety of G.M. foods." G.M. is a commonly used term meaning genetically modified. In another article on lectin in the same issue of The Lancet, Scottish researchers suggest that more studies must be done on the safety of lectin before its genes are used to make crops insect resistant. The study, by scientists at the Scottish Crop Research Institute and the University of Dundee, found that snowdrop lectin can bind to human white blood cells in a test tube. The authors said the results defied the conventional view that the snowdrop lectin would not affect humans. Editors of peer-reviewed journals say it is not unusual to publish papers opposed by a minority of the reviewers. But some questioned whether it was proper to publish any article found scientifically lacking merely to present data to the public, especially when scientists can now publicize their own results on the Internet. "To me, it tarnishes the reputation of the journal that publishes it," said Floyd E. Bloom, editor of Science. "If you're just going to take it because it's controversial, well, there are a whole lot of controversial things." [In 1988, the journal Nature published a seemingly implausible article saying that antibodies were effective even when diluted to the point where there were no molecules left, perhaps because the water retained some "memory" of the antibodies. Nature published an editorial in the same issue warning readers to beware and said one reason it published the study was to avoid charges of suppressing an important discovery. A few weeks later, an investigative team sent by Nature to the laboratory involved debunked the study.] ================================= *** NOTICE: In accordance with Title 17 U.S.C. Section 107, this material is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. *** DECLARATION & DISCLAIMER ========== CTRL is a discussion and informational exchange list. Proselyzting propagandic screeds are not allowed. Substance—not soapboxing! These are sordid matters and 'conspiracy theory', with its many half-truths, misdirections and outright frauds is used politically by different groups with major and minor effects spread throughout the spectrum of time and thought. That being said, CTRL gives no endorsement to the validity of posts, and always suggests to readers; be wary of what you read. CTRL gives no credeence to Holocaust denial and nazi's need not apply. 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