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Nipah virus a rare new genus - study


WASHINGTON, May 26 (Reuters) - The Nipah virus that killed 106 people in
Malaysia and Singapore and caused livestock breeders to slaughter more than 1
million pigs in 1999 is a member of a new genus of viruses, researchers said
on Friday.

They said it was related to a mysterious virus, since named Hendra virus,
that sickened horses and killed two people in Australia in 1994.

The two species of virus make up their own genus, said William Bellini of the
U.S. Centres for Disease Control and Prevention (CDC) and colleagues at the
University of Malaya Medical Centre in Kuala Lumpar, Malaysia, Australia's
Commonwealth Scientific and Industrial Research Organisation and elsewhere.

``We suggest that these two viruses are representative of a new genus within
the family Paramyxoviridae,'' they wrote in their report, published in
Friday's issue of the journal Science.

What the two viruses have in common, they said, is an ability to make people
ill. ``Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in
its ability to infect and cause potentially fatal disease in a number of host
species, including humans,'' they wrote.

Nipah, apparently passed by coughing pigs, can lead to deadly encephalitis in
people. It caused more than 265 causes in Malaysia and Singapore in 1998 and
1999.

The researchers did a number of tests to try to identify Nipah and found it
did not react with measles virus, herpes, enteroviruses or other strains, but
did strongly react with antiserum for Hendra virus from Australia.

``The emergence of Hendra virus in two outbreaks of severe respiratory virus
disease in thoroughbred horses in Brisbane and MacKay, Queensland, Australia,
in 1994 provided the first glimpse of a zoonotic (animal) paramyxovirus with
an expanded host range that includes humans,'' they wrote.

``Under experimental conditions, Hendra virus was shown to infect cats,
guinea pigs, horses and fruit bats.''

Genetic analysis confirmed Nipah and Hendra were closely related enough to
make up their own genus.

They said experiments suggested bats were the natural host of the Nipah virus
but tests have yet to turn up an infected bat. ``Thus, the reservoir of Nipah
virus and the source of the virus that initiated the outbreak remain open
questions,'' they wrote.

Many animal viruses pass to people -- notably influenza, from pigs and ducks
and the HIV virus that causes AIDS from people -- but this family of viruses
had not been known to before.

11:39 05-26-00
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