-Caveat Lector-

Smoking is smoking is smoking... Because of the unregulated nature of
marijuana production and sale, marijuana growers have no incentive to
control the amount of tar in their product. In addition, most marijuana
smokers hold the smoke in the respiratory tract far longer than is normal
with tobacco smoke. Verb. sap.

http://www.medscape.com/reuters/eline/tue/t1227-3f.html

Smoking Marijuana Increases Head And Neck Cancer Risk

NEW YORK, Dec 27 (Reuters Health) -- People who smoke marijuana may be more
likely than those who do not smoke to develop cancer of the head and neck,
according to a report in the December 17th issue of Cancer Epidemiology
Biomarker and Prevention.

"Many people may think marijuana is harmless, but it's not," said study
author Dr. Zuo-Feng Zhang, in a statement issued by the University of
California, Los Angeles.

The more often each day a person smokes marijuana, and the longer they
continue to smoke it, the greater their chance of developing cancer in
places such as the mouth, tongue, larynx or pharynx, according to the study
by Zhang, of UCLA's Jonsson Comprehensive Cancer Center, and colleagues.

The researchers compared marijuana, alcohol and tobacco use in 173 patients
who had cancer of the head and neck with that of 176 blood donors who did
not have cancer.

When they eliminated other factors that contribute to cancer, including
smoking and alcohol intake, they found that people who smoked marijuana at
any point during their lifetime were 2.6 times more likely to develop head
and neck cancer compared with people who had never smoked marijuana.

The risk increased in relation to the amount of the drug used and the number
of years a person smoked marijuana.

"If you smoke a little, your risk increases a little," Zhang said. "If you
smoke a lot, your risk increases a lot."

Marijuana may interact with a genetic susceptibility to such cancers, with
cigarette smoking, and, to a lesser extent, with alcohol consumption to
increase a person's chances of developing head and neck cancer, according to
the report.

Back in the 1960s, many people in their twenties smoked marijuana, Zhang
points out. Because cancers of the head and neck take 20 to 30 years to
develop, individuals who smoked large amounts of marijuana 20 to 30 years
ago may just now be developing head and neck cancer.

The researchers note that the blood donors, the comparison group in the
study, may have been less likely than the cancer patients to have used
marijuana.

Or it is possible that the cancer patients were more likely than the blood
donors to remember and report marijuana use.

Either factor could bias the study, which should be confirmed with more
research, the research team says.

Although it's known that the cancer-causing properties of marijuana smoke
are similar to those of cigarette smoke, this is the first study in which
investigators have looked at the relationship between smoking marijuana and
head and neck cancer, Zhang said.

It is estimated that approximately 31% of adults in the United States use
marijuana.

Cancer Epidemiology Biomarker and Prevention 1999;1071-1078.

Copyright © 1999 Reuters Ltd. All rights reserved. Republication or
redistribution of Reuters content is expressly prohibited without the prior
written consent of Reuters. Reuters shall not be liable for any errors or
delays in the content, or for any actions taken in reliance thereon.




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