-Caveat Lector-

Thursday August 2 1:28 PM ET

Soy Protein Suppresses Breast Cancer Hormones

By Suzanne Rostler

NEW YORK (Reuters Health) - Antioxidant compounds found in soy foods
have been shown to reduce levels of hormones associated with breast
cancer risk in women. Now, the results of a small study suggest that other
factors associated with soy may also play a role in lowering cancer risk.

The investigators found that nine healthy, premenopausal women who
consumed a diet containing soymilk in which most of the antioxidant
compounds, isoflavones, had been removed, produced less estrogen and
progesterone than they produced before they added soy to their diets. Other
reproductive hormones were not affected by the diet, which was also low in
animal protein and high in fiber, the researchers report.

According to the study in the July issue of the Journal of Clinical
Endocrinology and Metabolism, estrogen levels fell as soy protein and fiber
intake increased.

However, Dr. Lee-Jane W. Lu, the study's lead author, stressed that it is not
yet clear which dietary compounds caused the change in hormone levels.

``The important finding from my study is that it is not too hard to lower a
woman's...female hormone,'' she told Reuters Health. ``By replacing--not
supplementing--a portion of one's energy intake (with) soy, one can lower
one's female hormones.''

Estrogen can stimulate the growth of some types of breast cancer cells and
is thought to play a role in the development of some cases of breast cancer.
Women with a higher lifetime exposure to estrogen--for instance, those who
got their first period at an early age, those who do not have children and
women who do not breastfeed--may face a higher risk of breast cancer. The
hormone progesterone also contributes to breast cancer risk by helping
tumors to grow.

``Our results may have implications for breast cancer prevention by soy
dietary intervention,'' according to Lu and her colleagues at the University of
Texas Medical Branch in Galveston.

In the study, researchers measured levels of estrogen, progesterone, sex
hormone-binding globulin, luteinizing hormone (LH) and follicle stimulating
hormone (FSH) in women before they began the diet. LH and FSH stimulate
ovarian function.

The women followed the diet, which included 36 ounces of soymilk containing
less than 5 milligrams of isoflavones daily, for one month. The study diet
contained more carbohydrate and less protein than the women's usual diets,
the report indicates.

SOURCE: Journal of Clinical Endocrinology and Metabolism 2001;86:3045-


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