I have also observed a similar behavior
with Ubuntu 20.04

lspci | grep Audio

09:00.1 Audio device: Advanced Micro Devices, Inc. [AMD/ATI] Ellesmere HDMI 
Audio [Radeon RX 470/480 / 570/580/590]
0b:00.4 Audio device: Advanced Micro Devices, Inc. [AMD] Starship/Matisse HD 
Audio Controller

uname -a

Linux jrechenknecht7 5.4.0-73-generic #82-Ubuntu SMP Wed Apr 14 17:39:42
UTC 2021 x86_64 x86_64 x86_64 GNU/Linux

and Firefox 88.0.1 (AMD64 Platform).

For me this bug also causes other applications to be distorted, too.

 sudo lshw -C sound

sudo lshw -C sound
  *-usb:4                   
       Beschreibung: Audio-Gerät
       Produkt: HD Webcam C615
       Hersteller: Logitech, Inc.
       Physische ID: a
       Bus-Informationen: usb@1:a
       Version: 0.11
       Seriennummer: 4B9FE1D0
       Fähigkeiten: usb-2.00 audio-control
       Konfiguration: driver=uvcvideo maxpower=500mA speed=480Mbit/s
  *-multimedia
       Beschreibung: Audio device
       Produkt: Ellesmere HDMI Audio [Radeon RX 470/480 / 570/580/590]
       Hersteller: Advanced Micro Devices, Inc. [AMD/ATI]
       Physische ID: 0.1
       Bus-Informationen: pci@0000:09:00.1
       Version: 00
       Breite: 64 bits
       Takt: 33MHz
       Fähigkeiten: pm pciexpress msi bus_master cap_list
       Konfiguration: driver=snd_hda_intel latency=0
       Ressourcen: irq:100 memory:fce60000-fce63fff
  *-multimedia
       Beschreibung: Audio device
       Produkt: Starship/Matisse HD Audio Controller
       Hersteller: Advanced Micro Devices, Inc. [AMD]
       Physische ID: 0.4
       Bus-Informationen: pci@0000:0b:00.4
       Version: 00
       Breite: 32 bits
       Takt: 33MHz
       Fähigkeiten: pm pciexpress msi bus_master cap_list
       Konfiguration: driver=snd_hda_intel latency=0
       Ressourcen: irq:102 memory:fc900000-fc907fff

Note that the behavior occurred when the Logitex C615 has been unplugged.
I was just curious, because Dave Evans has the same webcam so I could not 
exclude that
this may be related.

-- 
You received this bug notification because you are a member of Desktop
Packages, which is subscribed to firefox in Ubuntu.
https://bugs.launchpad.net/bugs/1906741

Title:
  Firefox sometimes causes garbled audio

Status in firefox package in Ubuntu:
  Confirmed
Status in pulseaudio package in Ubuntu:
  Confirmed

Bug description:
  Opening certain applications/websites at the same time as Firefox
  causes the audio to become garbled.

  The audio sounds distorted with an echo.

  Certain actions are guaranteed to cause this, but it can also
  happening when only running instances of Firefox.

  I've been able to consistently cause this by launching Zoom from a link 
within Firefox. 
  This does not occur when using Chrome. 

  The only way to fix the issue is to shut down all audio-related
  programs.

  ProblemType: Bug
  DistroRelease: Ubuntu 20.04
  Package: firefox 83.0+build2-0ubuntu0.20.04.1
  ProcVersionSignature: Ubuntu 5.4.0-56.62-generic 5.4.73
  Uname: Linux 5.4.0-56-generic x86_64
  NonfreeKernelModules: nvidia_modeset nvidia
  AddonCompatCheckDisabled: False
  ApportVersion: 2.20.11-0ubuntu27.12
  Architecture: amd64
  AudioDevicesInUse:
   USER        PID ACCESS COMMAND
   /dev/snd/controlC2:  rdevans   55475 F.... pulseaudio
   /dev/snd/controlC0:  rdevans   55475 F.... pulseaudio
   /dev/snd/controlC3:  rdevans   55475 F.... pulseaudio
   /dev/snd/controlC1:  rdevans   55475 F.... pulseaudio
  BuildID: 20201112153044
  CasperMD5CheckResult: skip
  Channel: Unavailable
  CurrentDesktop: ubuntu:GNOME
  Date: Thu Dec  3 16:55:36 2020
  Extensions: extensions.sqlite corrupt or missing
  ForcedLayersAccel: False
  IfupdownConfig:
   # interfaces(5) file used by ifup(8) and ifdown(8)
   auto lo
   iface lo inet loopback
  IncompatibleExtensions: Unavailable (corrupt or non-existant 
compatibility.ini or extensions.sqlite)
  InstallationDate: Installed on 2017-10-20 (1140 days ago)
  InstallationMedia: Ubuntu 17.04 "Zesty Zapus" - Release amd64 (20170412)
  IpRoute:
   default via 10.0.0.1 dev enp7s0 proto dhcp metric 100 
   10.0.0.0/24 dev enp7s0 proto kernel scope link src 10.0.0.7 metric 100 
   169.254.0.0/16 dev enp7s0 scope link metric 1000
  Locales: extensions.sqlite corrupt or missing
  PrefErrors: Unexpected character ',' before close parenthesis @ 
/usr/lib/firefox/omni.ja:greprefs.js:354
  PrefSources: prefs.js
  Profiles: Profile0 (Default) - LastVersion=83.0/20201112153044 (In use)
  RunningIncompatibleAddons: False
  SourcePackage: firefox
  Themes: extensions.sqlite corrupt or missing
  UpgradeStatus: Upgraded to focal on 2020-11-12 (21 days ago)
  dmi.bios.date: 02/18/2011
  dmi.bios.vendor: American Megatrends Inc.
  dmi.bios.version: P1.40
  dmi.board.name: H67M
  dmi.board.vendor: ASRock
  dmi.chassis.asset.tag: To Be Filled By O.E.M.
  dmi.chassis.type: 3
  dmi.chassis.vendor: To Be Filled By O.E.M.
  dmi.chassis.version: To Be Filled By O.E.M.
  dmi.modalias: 
dmi:bvnAmericanMegatrendsInc.:bvrP1.40:bd02/18/2011:svnToBeFilledByO.E.M.:pnToBeFilledByO.E.M.:pvrToBeFilledByO.E.M.:rvnASRock:rnH67M:rvr:cvnToBeFilledByO.E.M.:ct3:cvrToBeFilledByO.E.M.:
  dmi.product.family: To Be Filled By O.E.M.
  dmi.product.name: To Be Filled By O.E.M.
  dmi.product.sku: To Be Filled By O.E.M.
  dmi.product.version: To Be Filled By O.E.M.
  dmi.sys.vendor: To Be Filled By O.E.M.

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