If you use VueScan you can certainly manually enter focus values.

With the new version 7.0.10 and a better alignment for multipass scans I'm going to 
try with a negative that is grain aliased badly in skin tones a multipass scan with 
focus set to SCAN so the multiple images are focused at slightly different values and 
observe the difference.

alan

 >>  I can!  I'm experimenting with many different ways to help with 
 >>  grain-aliasing on neg's on my Acer 2720, and de-focussing can 
 >>  help..  Because the Acer does not have manual focus, I have to trick it by
 >>  
 >>  using a dummy frame, but it can be done..  It's not the holy grail, but it
 >>  
 >>  is one more useful tool.

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