Re: [Freesurfer] Pet Surfer

2018-10-10 Thread Greve, Douglas N.,Ph.D.
It could make sense to apply it to WM. CSF I'm not so sure. Are you really trying to measure the signal in CSF? On 10/10/18 6:08 PM, David.Mackarthy wrote: > External Email - Use Caution > > Dear Dr Greve, thank you for the response > This is for a map-based study. Absolutely, this is cl

Re: [Freesurfer] Pet Surfer

2018-10-10 Thread David.Mackarthy
External Email - Use Caution Dear Dr Greve, thank you for the response This is for a map-based study. Absolutely, this is clear, I appreciate the response. I just have one additional question and I appreciate your patience. Is it recommended to apply PVC on white matter or csf? d

Re: [Freesurfer] Pet Surfer

2018-10-10 Thread Greve, Douglas N.,Ph.D.
Is this for an ROI-based study or a map-based study? For ROI, we use the GTM, and it PV corrects for all structures (including WM and CSF). For map-based, we use MG. MG removes WM (and CSF) entirely. In theory, it can be run in a way to keep WM and throw GM and CSF away, but that is not impleme

[Freesurfer] Pet Surfer

2018-10-10 Thread David.Mackarthy
External Email - Use Caution Dear Dr Greeve, I am following petsurfer pipeline to do surface based analysis of PET-FDG data and I have interest in doing partial volume correction. I would like to inquire about: 1) Can partial volume correction be applied on white mater, or just

Re: [Freesurfer] pet surfer

2017-08-18 Thread Douglas Greve
PVC will increase signal in some regions and will decrease it in others. Eg, for FDG it will increase it in GM and decrease it in WM. The reason you are seeing such a wide range is that the MG correction subtracts the WM then divides by the GM partial volume fraction (PVF, a number between 0 a

Re: [Freesurfer] pet surfer

2017-08-18 Thread John Anderson
Hi Dr Greve, Thank you very much for the great answers. Kindly, I have one last question. The range of the signal intensity within the voxels in the original SUV maps is min=0.00 and max=3.017629 For the mgx images it is min=-43.74384 and max=88.468712 The difference in the range of signal inten

Re: [Freesurfer] pet surfer

2017-08-18 Thread Douglas Greve
On 8/18/17 10:20 AM, John Anderson wrote: Hi Dr Greve, I followed the steps in WIKI to do SUV-surface based analyses + PVC. I have the following questions and I highly appreciate your input: 1. Why the dimension of the images (mgx.gm, mgx.ctx.gm and mgx.ctx.subgm) is not like the original

[Freesurfer] pet surfer

2017-08-18 Thread John Anderson
Hi Dr Greve, I followed the steps in WIKI to do SUV-surface based analyses + PVC. I have the following questions and I highly appreciate your input: 1. Why the dimension of the images (mgx.gm, mgx.ctx.gm and mgx.ctx.subgm) is not like the original SUV image that has been fed to the pipeline. i.

Re: [Freesurfer] PET surfer

2017-08-11 Thread John Anderson
Hi Dr Greve, Thanks again for the great explanation and for clarifying how smoothing may exacerbate the partial volume effects. I have additional question and I appreciate your answer: In the literature of the voxel-wise analysis using FSL/randomise to study the difference between two groups

Re: [Freesurfer] PET surfer

2017-08-10 Thread Douglas N Greve
On 08/10/2017 11:35 AM, John Anderson wrote: > > Dear Dr Greve, > > Thank you very much for the great explanation. I will definitely > correct for PVC using PET surfer. > > Kindly I have one follow-up question and I highly appreciate your input. > > I have PET data for two groups. I studied the

Re: [Freesurfer] PET surfer

2017-08-10 Thread John Anderson
Dear Dr Greve, Thank you very much for the great explanation. I will definitely correct for PVC using PET surfer. Kindly I have one follow-up question and I highly appreciate your input. I have PET data for two groups. I studied the difference in PET signal using voxel-wise ( FSL/randomise) a

Re: [Freesurfer] PET surfer

2017-08-10 Thread Douglas N Greve
The PET signal can change with a lot of anatomical changes in the brain including thickness, surface area, and gyrification. There is no known regressor that will account for this. Right right way to account for it is with partial volume correction (PVC). It is best to do PVC simultaneously w

[Freesurfer] PET surfer

2017-08-10 Thread John Anderson
Hi Dr Greve, I have PET data for two groups and I used PET surfer in FSV 6.0 to run the analyses. The pipeline is straightforward and the analysis ran smoothly without any issues. Is it correct procedure to adjust PET signal to differences in gray matter volume or cortical thinness between two