Unfortunately some controls cannot be confidently used in a TMA eg CD15 - where
often Hodgkin's cells are sparse in the block, or CMV or adenovirus - again
same reason - sparse positive cells. We sometimes use composite blocks, eg skin
and lymph node for S100 and CD1a - (dendritic cells) or (in
This is what we've done when we recently moved to control tissue on every slide
for IHC as well as Special Stains.
Linda A. Sebree
University of Wisconsin Hospital & Clinics
IHC/ISH Laboratory
600 Highland Ave.
Madison, WI 53792
(608)265-6596
FAX: (608)262-7174
-Original Message-
